Title:
第XI因子による炎症反応のモジュレーション
Document Type and Number:
Japanese Patent JP2012524068
Kind Code:
A
Abstract:
Disclosed herein are antisense compounds and methods for modulating Factor XI and modulating an inflammatory disease, disorder or condition in an individual in need thereof. Inflammatory diseases in an individual such as arthritis and colitis can be ameliorated or prevented with the administration of antisense compounds targeted to Factor XI.
Inventors:
Brett Pea, Monia
Crosby, Jeffrey Earl
McCloud, Robert A.
Flair, Susan M
Crosby, Jeffrey Earl
McCloud, Robert A.
Flair, Susan M
Application Number:
JP2012505942A
Publication Date:
October 11, 2012
Filing Date:
April 15, 2010
Export Citation:
Assignee:
Isis Pharmaceuticals, Inc.
International Classes:
A61K45/00; A61K31/7088; A61P1/04; A61P3/06; A61P3/10; A61P11/06; A61P19/02; A61P19/06; A61P29/00; A61P31/10; A61P37/06; C12N15/113
Foreign References:
| WO2008017081A1 | 2008-02-07 | |||
| WO2008066776A2 | 2008-06-05 | |||
| WO2009046141A2 | 2009-04-09 |
Other References:
JPN7013004305; Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｉｎｆｅｃｔｉｏｕｓ Ｄｉｓｅａｓｅｓ Ｖｏｌ．１９８， Ｎｏ．２, 2008, ｐ．２７１-２７４
JPN6013058346; Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｉｎｖｅｓｔｉｇａｔｉｏｎ Ｖｏｌ．１０７， Ｎｏ．５, 2001, ｐ．６３１-６４０
JPN6013058347; 本郷利憲・廣重力・豊田順一 監修: 標準生理学 第６版, 2005, ｐ．５０６-５０８, 株式会社 医学書院
JPN6013058346; Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｉｎｖｅｓｔｉｇａｔｉｏｎ Ｖｏｌ．１０７， Ｎｏ．５, 2001, ｐ．６３１-６４０
JPN6013058347; 本郷利憲・廣重力・豊田順一 監修: 標準生理学 第６版, 2005, ｐ．５０６-５０８, 株式会社 医学書院
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri