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Title:
変異HIVgag/pol、SIVgagおよびSIVenv遺伝子を持つ分子クローン
Document Type and Number:
Japanese Patent JP4627950
Kind Code:
B2
Abstract:
Nucleic acid constructs containing HIV-1 gag / pol and SIV gag or SIV env genes which have been mutated to remove or reduce inhibitory/instability sequences are disclosed. Viral particles and host cells containing these constructs and/or viral particles are also disclosed. The exemplified constructs and viral particles of the invention may be useful in gene therapy for numerous disorders, including HIV infection, or as a vaccine for HIV-1 immunotherapy and immunoprophylaxis.

Inventors:
Pabrakis, George N
Application Number:
JP2001546906A
Publication Date:
February 09, 2011
Filing Date:
December 22, 2000
Export Citation:
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Assignee:
THE UNITED STATES OF AMERICA
International Classes:
C12N15/09; A61K31/7088; A61K39/00; A61K39/21; A61P31/18; C07K14/155; C07K14/16; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N5/22; C12N7/00; C12N15/867; A61K48/00
Domestic Patent References:
JP7509121A
Foreign References:
WO1999061596A1
Other References:
J. Virol.,1998年,vol.72, no.11,pp.8873-8883
J. Virol.,1997年 7月,vol.71, no.7,pp.4892-4903
Science,1996年 4月,vol.272, no.5259,pp.263-267
J. Virol.,1998年,vol.72, no.11,pp.8463-8471
Proc. Natl. Acad. Sci. U.S.A.,1994年,vol.91, no.4,pp.1256-1260
J. Virol.,1997年,vol.71, no.8,pp.5841-5848
J. Virol.,1998年,vol.72, no.1,pp.811-816
J. Virol.,1999年 3月,vol.73, no.3,pp.1828-1834
J. Virol.,1999年11月,vol.73, no.11,pp.9145-9152
J. Virol.,1991年10月,vol.65, no.10,pp.5305-5313
J. Virol.,1992年12月,vol.66, no.12,pp.7176-7182
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri



 
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