Title:
神経変性疾患の治療に有用な分子標的及び化合物並びにこれらの同定方法
Document Type and Number:
Japanese Patent JP2011517339
Kind Code:
A
Abstract:
The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing polyglutamine-induced protein aggregation, and/or altering huntingtin protein conformation, which inhibition is useful in the prevention, amelioration and/or treatment of neurodegenerative diseases, and protein aggregation diseases more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and/or treatment of Huntington's disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these
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Inventors:
David Frederik Huischel
Richard Antonius Joseph Janssen
Remco Deprill
Desile Maria Petronella Catharina Van Stehenhoven
Seung Kwak
David S. Holland
Ethan signer
Richard Antonius Joseph Janssen
Remco Deprill
Desile Maria Petronella Catharina Van Stehenhoven
Seung Kwak
David S. Holland
Ethan signer
Application Number:
JP2010544729A
Publication Date:
June 02, 2011
Filing Date:
February 03, 2009
Export Citation:
Assignee:
Galapagos N.V.
International Classes:
G01N33/566; A61K31/7088; A61K31/7105; A61K48/00; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; C12N15/113; G01N33/15; G01N33/50; G01N33/53
Attorney, Agent or Firm:
Toru Ishikawa