Title:
放射性同位元素で標識したアルカン酸を使用することによる血流および組織への代謝的取込みのモニター法
Document Type and Number:
Japanese Patent JP4633052
Kind Code:
B2
Abstract:
The present invention relates to novel modified fatty acid analogs, where a positron or gamma-emitting label is placed at a position on a fatty acid backbone and an organic substituent is substituted at the 2,3; 3,4; 4,5; 5,6 and other sequence positions of a fatty acid backbone. These novel fatty acid analogs are designed to enter the tissues of interest by the same long chain fatty acid carrier mechanism as natural fatty acids, however, functional substituents in the 2,3; 3,4; 4,5; 5,6 and other sequence positions, block the catabolic pathway, thus trapping these analogs in a virtually unmodified form in the tissues of interest.
Inventors:
El Murray, David Earl
Alan Jay, Fishman
Shawup, Timothy M
Alan Jay, Fishman
Shawup, Timothy M
Application Number:
JP2006513138A
Publication Date:
February 16, 2011
Filing Date:
April 19, 2004
Export Citation:
Assignee:
The General Hospital Corporation
International Classes:
C07C53/23; A61K31/19; A61K31/20; A61K51/00; B65D71/00; C07C57/56; C07C57/62; C07C61/04; C07C63/33; C07F5/00; C07B59/00; A61B
Foreign References:
| DE4012405C2 |
Other References:
Journal of Nuclear Medicine,Vol.38, No.12,p.1864-1869 (1997).
Bulleteion of Environmental Contamination and Toxicology,Vol.22, No.4-5,p.462-466 (1979).
Bulleteion of Environmental Contamination and Toxicology,Vol.22, No.4-5,p.462-466 (1979).
Attorney, Agent or Firm:
Yanagita Seiji
Go Sakuma
Go Sakuma