MONO- AND BICYCLIC AZOLE DERIVATIVES THAT INHIBIT THE INTERACTION OF LIGANDS WITH RAGE

Japanese Patent JP2009096806

A

To provide compounds which are modulators of the receptor for advanced glycated end products (RAGE) and to provide a pharmaceutical compositions comprising the compounds.

The invention provides compounds of formula I, (wherein A1 is O, S or -N(R2)-, R1 is H, an aryl, etc., R2 is H, an aryl, etc., R3 and R4 are each independently H, a halogen atom etc.), and the pharmaceutical compositions comprising the compounds. The compounds of the invention are useful for acute and chronic inflammation, increased vascular permeability, nephropathy, atherosclerosis, and development of diabetic late complications, such as retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.

MJALLI ADNAN M M
ANDREWS ROBERT C
GOPALASWAMY RAMESH
HARI ANITHA
AVOR KWASI
QABAJA GHASSAN
GUO XIAO-CHUAN
GUPTA SUPARNA
JONES DAVID R
CHEN XIN

JP2008271566A

May 07, 2009

October 22, 2008

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TRANSTECH PHARMA INC

C07D233/64; A61K9/12; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/42; A61K31/422; A61K31/439; A61K31/4439; A61K31/444; A61K31/454; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/496; A61K31/506; A61K31/5377; A61K31/55; A61K45/00; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P15/10; A61P17/00; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P35/04; A61P43/00; C07D233/54; C07D235/08; C07D235/12; C07D235/14; C07D235/18; C07D235/30; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/04; C07D405/12; C07D413/12; C07D453/02; C07D235/10

JP2001509814A

2001-07-24

Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takumi Terachi

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