モノアシル化ベツリンおよびジヒドロベツリン誘導体、その製造および使用

Title:

モノアシル化ベツリンおよびジヒドロベツリン誘導体、その製造および使用

Document Type and Number:

Japanese Patent JP2006504704

Kind Code:

A

Abstract:

Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have Formula I as described herein, or pharmaceutically acceptable salts thereof, wherein R1 is a C2-C20 substituted or unsubstituted carboxyacyl, R2 is hydrogen, chloro, bromo, or hydroxy, R4 is hydrogen or C(C6H5)3; wherein the dashed line represents an optional double bond between C20 and C29.

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Inventors:

Graham P. Away
Carl T. Wild
Yoshiki Kashiwa
Kuo-Shun Lee

Application Number:

JP2004539897A

Publication Date:

February 09, 2006

Filing Date:

September 26, 2003

Export Citation:

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Assignee:

Panakos Pharmaceuticals, Inc.
Niigata Science and Technology Academy Niigata Pharmaceutical University

International Classes:

A61K31/513; C07J63/00; A61K31/52; A61K31/56; A61K31/662; A61K31/7072; A61K39/00; A61K45/00; A61K45/06; A61P31/12; A61P31/14; A61P31/18; A61P43/00; C07J53/00

Attorney, Agent or Firm:

Kyousei Tamura
Yushiro Tsuboi
Nagatoshi Shinagawa

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