Title:
モノアミン受容体及び輸送体のリガンドならびにその使用方法
Document Type and Number:
Japanese Patent JP2004509103
Kind Code:
A
Abstract:
One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.
Inventors:
Aquila, Brian M
Bannister, Thomas Dee
Kanny, Gregory Dee
Hosk, james are
Holland, Joanne M
Parsons, Paul Yee
Radik, Haiku
Wang, Feng Jiang
Xiao, Rimin
Bannister, Thomas Dee
Kanny, Gregory Dee
Hosk, james are
Holland, Joanne M
Parsons, Paul Yee
Radik, Haiku
Wang, Feng Jiang
Xiao, Rimin
Application Number:
JP2002526825A
Publication Date:
March 25, 2004
Filing Date:
September 12, 2001
Export Citation:
Assignee:
Sepreiko Inc.
International Classes:
C07D223/04; A61K31/397; A61K31/40; A61K31/445; A61K31/4525; A61K31/453; A61K31/454; A61K31/4545; A61K31/5355; A61K31/5375; A61K31/55; A61K31/553; A61P1/00; A61P1/08; A61P3/04; A61P9/12; A61P13/10; A61P15/00; A61P15/10; A61P25/00; A61P25/04; A61P25/06; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P29/00; A61P43/00; C07B61/00; C07C255/46; C07D205/02; C07D205/04; C07D207/06; C07D207/08; C07D207/09; C07D211/12; C07D211/14; C07D211/16; C07D211/18; C07D211/20; C07D211/22; C07D211/26; C07D211/32; C07D211/40; C07D211/42; C07D211/60; C07D233/04; C07D233/10; C07D265/30; C07D267/10; C07D303/08; C07D401/06; C07D401/12; C07D405/06; C07D405/12; C07D413/06; (IPC1-7): C07D211/18; A61K31/397; A61K31/40; A61K31/445; A61K31/4525; A61K31/453; A61K31/454; A61K31/4545; A61K31/5355; A61K31/5375; A61K31/55; A61K31/553; A61P1/00; A61P1/08; A61P3/04; A61P9/12; A61P13/10; A61P15/00; A61P15/10; A61P25/00; A61P25/04; A61P25/06; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P29/00; A61P43/00; C07D205/04; C07D207/08; C07D211/14; C07D211/16; C07D211/20; C07D211/22; C07D211/26; C07D211/32; C07D211/42; C07D211/60; C07D223/04; C07D265/30; C07D267/10; C07D401/06; C07D401/12; C07D405/06; C07D405/12; C07D413/06
Attorney, Agent or Firm:
Yanagita Seiji
Go Sakuma
Go Sakuma