ヒトのラミニン５アルファ３鎖のＬＧ４−５ドメインに対するモノクローナル抗体

Japanese Patent JP5795538

B2

The present invention relates to a monoclonal antibody binding to the LG4-5 domain of chain ±3 of human protein laminin-5, wherein said monoclonal antibody inhibits the binding of syndecan-1 to said laminin-5 ±3 chain LG4-5 domain, in particular 1H12 monoclonal antibody produced by the hybridoma cell line named 1H12 deposited on January 8, 2008 at the C.N.C.M. under number 1-3890, as well as chimerized, humanized derivatives and fragments thereof, and nucleic acid sequences encoding them, as well as vectors and host cells expressing them. The invention further relates to the medical application of such antibodies, in particular for treating cancer.

Roussel, Patricia
Le Tournal, Francois

JP2011541493A

October 14, 2015

December 18, 2009

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Center Nacional de la Rushche Santi Fique (Seienères)
UNIVERSITE CLAUDE BERNARD LYON 1

C12N15/09; A61K39/395; A61K48/00; A61P35/00; C07K16/30; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/02; G01N33/50

WO2005073254A2

L.E.Goldfinger, et al,Journal of Cell Science,1999年,Vol.112,pp.2615-2629
D.E.Frank, et al,Journal of Cell Science,2003年,Vol.117,pp.1351-1363
O.Okamoto,et al,The Journal of Biological Chemistry,2003年,Vol.278, No.45,pp.44168-44177
S.Bachy, et al,Journal of Cellular Physiology,2007年,Vol.214,pp.238-249
M.Tran, et al,Cancer Research,2008年 4月,Vol.68, No.8,pp.2885-2894

Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki
Junzo Koike
Hirofumi Toma

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