PURPOSE: To obtain a dinucleoside analogue useful for treatment of virus diseases such as influenza, herpes and HIV and a mononucleoside analogue used for intermediates or the like for production of an oligonucleoside.
CONSTITUTION: This compound is represented by formula I [R1 is H or a protective group Q (for protecting p-H); R22 is H, a 1-8C aliphatic group or the like; R3 and R4 are independently H, a halogen or hydroxy; R5 is a 6-10C aryloxythiocarbonyloxy or the like; R6 is H, a 1-10C aliphatic group or the like; R7 is a monovalent nucleoside base group], e.g. a compound of formula II. The compound of formula I is obtained by reacting a compound of formula III (B is a monovalent nucleoside base group; R5a is H, F or the like) with an organometallic compound of formula IV [Qa is formula V (R10 is H, a 1-10C alkyl or the like; R11 and R12 are independently a 1-10C alkyl); R2a is a 1-8C alkyl or the like; M is Li or Mg] in the presence of a Lewis acid.
ERITSUKU KIISU BEIRISU
SUTEFUAN POORU KOORINGUUTSUDO
ROJIYAA JIYON TEIRAA
ARAN DOU MESUMEEKAA
HANTARU SHIYUMITSUTO
