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Title:
MOUSE GENE CORRESPONDING TO CAUSATIVE GENE OF HUMAN WERNER'S SYNDROME AND PROTEIN FOR WHICH THE GENE CODES
Document Type and Number:
Japanese Patent JPH10146188
Kind Code:
A
Abstract:

To obtain the subject new gene corresponding to a causative gene of human Werner's syndrome (WRN), consisting of a mouse WRN gene coding for a polypeptide containing a specific amino acid sequence and useful as a reagent for detecting a WRN gene, etc.

A new mouse WRN gene coding for a polypeptide substantially containing an amino acid sequence expressed by the formula. The gene corresponds to a causative gene of human Werner's syndrome, is useful for a study to elucidate the relation to the occurrence of human WRN and to clarify a mechanism controlling the homeostasis of a living body, and is useful as a diagnostic probe for tests or prophylaxis of diseases related to the occurrence of WRN, etc. This gene is obtained by amplifying a DMA fraction having a partial sequence high in homology to the human WRN gene, and a DNA fraction whose sequence is unknown and a 3'-terminal-having DNA fraction whose sequence is unknown, both of these DNA fractions existing at the upstream side from that DNA fraction, and further fusing these DNA fractions.


Inventors:
IMAMURA TSUKASA
SUGAWARA MINORU
FURUICHI YASUHIRO
Application Number:
JP30472196A
Publication Date:
June 02, 1998
Filing Date:
November 15, 1996
Export Citation:
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Assignee:
EIJIIN KENKYUSHO KK
International Classes:
A01K67/027; C07K14/47; C07K16/18; C12N5/10; C12N15/00; C12P21/02; C12P21/08; C12Q1/68; C07K16/00; (IPC1-7): C12N15/00; A01K67/027; C07K14/47; C07K16/18; C12N5/10; C12P21/02; C12P21/08; C12Q1/68
Attorney, Agent or Firm:
Yusuke Hiraki (1 person outside)