To obtain the subject new gene corresponding to a causative gene of human Werner's syndrome (WRN), consisting of a mouse WRN gene coding for a polypeptide containing a specific amino acid sequence and useful as a reagent for detecting a WRN gene, etc.
A new mouse WRN gene coding for a polypeptide substantially containing an amino acid sequence expressed by the formula. The gene corresponds to a causative gene of human Werner's syndrome, is useful for a study to elucidate the relation to the occurrence of human WRN and to clarify a mechanism controlling the homeostasis of a living body, and is useful as a diagnostic probe for tests or prophylaxis of diseases related to the occurrence of WRN, etc. This gene is obtained by amplifying a DMA fraction having a partial sequence high in homology to the human WRN gene, and a DNA fraction whose sequence is unknown and a 3'-terminal-having DNA fraction whose sequence is unknown, both of these DNA fractions existing at the upstream side from that DNA fraction, and further fusing these DNA fractions.
SUGAWARA MINORU
FURUICHI YASUHIRO
