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Title:
MUC1 ANTIBODIES
Document Type and Number:
Japanese Patent JP2016041771
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide MUC1 antibodies.SOLUTION: The invention is directed to anti-mucin antibodies having improved antigen-binding and/or antigen recognition properties as well as a method for improving antigen binding and/or antigen recognition of an anti-mucin antibody. In particular, the invention is directed to anti-mucin antibodies useful for the treatment of cancer. In one embodiment, an antibody or a fragment or derivative thereof which is capable of binding to a mucin protein is provided, where the antibody or a fragment or derivative thereof comprises at least a portion of the heavy chain variable region which comprises a proline residue at amino acid position 28 according to the Kabat numbering.SELECTED DRAWING: Figure 3

Inventors:
GOLETZ STEFFEN
ANTJE DANIELCZYK
RENATE STAHN
UWE KARSTEN
Application Number:
JP2016000133A
Publication Date:
March 31, 2016
Filing Date:
January 04, 2016
Export Citation:
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Assignee:
GLYCOTOPE GMBH
International Classes:
C07K16/32; A61K39/395; A61K48/00; A61P11/00; A61P11/06; A61P35/00; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09
Domestic Patent References:
JPS5414785U1979-01-30
JP3192821B22001-07-30
Foreign References:
US20060292643A12006-12-28
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita