Title:
多剤リガンド結合体
Document Type and Number:
Japanese Patent JP5475992
Kind Code:
B2
Abstract:
Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations in a patient. The compounds described herein include conjugates of a plurality of cytotoxic drugs and vitamin receptor binding ligands. The plurality of drugs may be the same or different. Similarly, the vitamin receptor binding ligands may be the same or different. The conjugates also include a linker that is formed from one or more spacer linkers, heteroatom linkers, and releasable linkers.
Inventors:
Vrakhov, Ioncho, Radslavov
Lemon, Christopher, Paul
Lemon, Christopher, Paul
Application Number:
JP2008527205A
Publication Date:
April 16, 2014
Filing Date:
August 18, 2006
Export Citation:
Assignee:
End Site, Incorporated
International Classes:
A61K47/48; A61K31/407; A61K31/439; A61K31/519; A61K31/65; A61K47/42; A61P35/00
Domestic Patent References:
| JP2003512338A | ||||
| JP2002543111A |
Foreign References:
| WO2004069159A1 |
Other References:
LADINO, C.A. et al.,Int. J. Cancer,1997年,Vol.73,p.859-864
Attorney, Agent or Firm:
Isshiki International Patent Service Corporation