Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
MULTIMERS OF ANTIMICROBIAL PEPTIDES
Document Type and Number:
Japanese Patent JP2015145373
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide multimers of antimicrobial peptides, such as defensin peptides.SOLUTION: The present invention provides a multimer in which peptides derived from defensins (e.g., hBD3) are connected on a linear chain, a peptide multimer branched through two amine groups of amino acid such as lysine and ornithine, and methods of producing them. The multimers inhibit and/or reduce the growth of microorganisms in general, including in a host, and may be formulated into antimicrobial compositions, pharmaceutical compositions, eyedrop compositions, contact lens solutions, compositions for coating medical devices, and the like.

Inventors:
ROGER W BEUERMAN
LIU SHOUPING
LI JIN
ZHOU LEI
CHANDRA SHEKHAR VERMA
TAN DONALD
Application Number:
JP2015031712A
Publication Date:
August 13, 2015
Filing Date:
February 20, 2015
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SINGAPORE HEALTH SERV PTE LTD
AGENCY SCIENCE TECH & RES
International Classes:
C07K14/47; A61K38/00; A61P27/02; A61P31/04; G02C13/00
Domestic Patent References:
JP2006508720A2006-03-16
Foreign References:
WO2007007116A12007-01-18
WO2007126392A12007-11-08
WO2007025178A22007-03-01
Other References:
SCHIBLI, D.J., ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277(10), JPN6013054301, 2002, pages 8279 - 8289, ISSN: 0003253670
DHOPLE, V., ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1758, JPN6013054302, 2006, pages 1499 - 1512, ISSN: 0003253671
LIU, S., ET AL., CHEMBIOCHEM, vol. 8, JPN6013054304, 18 March 2008 (2008-03-18), pages 964 - 973, ISSN: 0003253672
ARNUSCH, C.J., ET AL., BIOCHEMISTRY, vol. 46, JPN6013054306, 2007, pages 13437 - 13442, ISSN: 0003253673
Attorney, Agent or Firm:
Ryu Iwatani



 
Previous Patent: L-ORNITHINE PHENYL ACETATE AND METHODS OF MAKING THE SAME

Next Patent: PRESBYOPIA TREATMENT BY LENS ALTERATION