Title:
複数置換の選択的アンドロゲンレセプタ修飾因子及びその使用方法
Document Type and Number:
Japanese Patent JP5113979
Kind Code:
B2
Abstract:
This invention provides androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor. The SARM compounds, either alone or as a composition, are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of acute and/or chronic muscular wasting conditions; e) preventing and/or treating dry eye conditions; f) oral androgen replacement therapy; and/or g) decreasing the incidence of, halting or causing a regression of prostate cancer.
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Inventors:
Dalton, James Tee
Miller, Duane Dee
Stainer, Mitchell Es
Bevelka, Karen Aye
Chen, Ji Yun
Fan, Dong Jin
Miller, Duane Dee
Stainer, Mitchell Es
Bevelka, Karen Aye
Chen, Ji Yun
Fan, Dong Jin
Application Number:
JP2003572923A
Publication Date:
January 09, 2013
Filing Date:
February 24, 2003
Export Citation:
Assignee:
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
International Classes:
A61P5/28; C07C237/20; A61K31/165; A61K31/167; A61K31/275; A61K31/655; A61P13/08; A61P15/16; A61P35/00; C07C233/05; C07C235/24; C07C247/16; C07C255/49; C07C331/08
Domestic Patent References:
| JP5933250A | ||||
| JP6330457A | ||||
| JP6330458A |
Foreign References:
| US6071957 | ||||
| WO1998053826A1 |
Attorney, Agent or Firm:
Yoichi Oshima
Masahiko Kimura
Tachikawa Yukio
Tomomi Takao
Yousuke Katsumi
Masahiko Kimura
Tachikawa Yukio
Tomomi Takao
Yousuke Katsumi