Title:
多価および多重特異性の結合タンパク質、それらの製造および使用
Document Type and Number:
Japanese Patent JP3720353
Kind Code:
B2
Abstract:
PCT No. PCT/GB93/02492 Sec. 371 Date May 14, 1996 Sec. 102(e) Date May 14, 1996 PCT Filed Dec. 3, 1993 PCT Pub. No. WO94/13804 PCT Pub. Date Jun. 23, 1994Polypeptides comprising a first domain, which comprises a binding region of an immunoglobulin heavy chain variable region, and a second domain, which comprises a binding region of an immunoglobulin light chain variable region, the domains being linked but incapable of associating with each other to form an antigen binding site, associate to form antigen binding multimers, such as dimers, which may be multivalent or have multispecificity. The domains may be linked by a short peptide linker or may be joined directly together. Bispecific dimers may have longer linkers. Methods of preparation of the polypeptides and multimers and diverse repertoires thereof, and their display on the surface of bacteriophage for easy selection of binders of interest, are disclosed, along with many utilities.
Inventors:
Holliger, Kasper-Philip
Griffiths, Andrew David
Fugen Boom, Hendricks Renels Jacobs Matthews
Malmukuvist, Magnus
Marks, James David
McGuinness, Brian Timothy
Anthony Richard, Pope
Terence Derek, Prospero
Winter, Gregory Paul
Griffiths, Andrew David
Fugen Boom, Hendricks Renels Jacobs Matthews
Malmukuvist, Magnus
Marks, James David
McGuinness, Brian Timothy
Anthony Richard, Pope
Terence Derek, Prospero
Winter, Gregory Paul
Application Number:
JP51392294A
Publication Date:
November 24, 2005
Filing Date:
December 03, 1993
Export Citation:
Assignee:
Medical Research Council
International Classes:
A61K39/395; C07K1/00; C07K2/00; C07K16/00; C07K16/46; C07K19/00; C12N1/21; C12N15/09; C12N15/10; C12N15/113; G01N33/531; C12N15/13; C12N15/62; C12N15/70; C12P21/02; C12P21/08; C40B40/02; A61K38/00; C12R1/19; (IPC1-7): C12N15/09; C07K16/00; C07K19/00; C12N1/21; C12P21/02; G01N33/531
Domestic Patent References:
| JP2000197A |
Foreign References:
| WO1993011161A1 |
Other References:
Proc Natl Acad Sci USA 90 p.6444-6448 (1993)
Attorney, Agent or Firm:
Takashi Ishida
Yoshio Yoshio
Masaya Nishiyama
Yoshio Yoshio
Masaya Nishiyama