Title:
Muscular tissue reproduction using a Muscle fiber fragment
Document Type and Number:
Japanese Patent JP6196217
Kind Code:
B2
Abstract:
The invention is directed to methods and compositions for obtaining uniform sized muscle fiber fragments for transplantation. These muscle fiber fragments are able to reconstitute into long fibers that are oriented along native muscle. The implanted muscle cells integrate with native vascular and neural network, as confirmed by histology and immunohistochemistry. This invention is particularly advantageous because autologous muscle can be harvested from a donor site, processed and injected into target sites in the operating room. The fragmented muscle fibers can be readily integrated within the host.
Inventors:
Anthony Atara
James yo
Coin cap
James yo
Coin cap
Application Number:
JP2014526151A
Publication Date:
September 13, 2017
Filing Date:
August 15, 2012
Export Citation:
Assignee:
Wake Forest University Health Sciences
International Classes:
A61L27/36; A61K35/34; A61L27/18; A61L27/20; A61L27/22; A61L27/24; A61L27/38; A61L27/44; A61L27/52; A61L27/54; A61P21/00
Domestic Patent References:
| JP2010529888A |
Other References:
J. Clin. Invest.,1996年,Vol.98, No.11,p.2512-2523
Developmental Biology,1986年,Vol.115,,p.129-139
Developmental Biology,1986年,Vol.115,,p.129-139
Attorney, Agent or Firm:
Kenji Sugimura
Hitomi Yuki
Koichiro God
Hitomi Yuki
Koichiro God