Title:
ロドバクター・スフェロイデス（Ｒｈｏｄｏｂａｃｔｅｒ ｓｐｈａｅｒｏｉｄｅｓ）由来の変異型３−ヒドロキシブチレート脱水素酵素及びそれを含む方法
Document Type and Number:
Japanese Patent JP6989528
Kind Code:
B2
Abstract:
The present invention relates to a mutant 3-hydroxybutyrate dehydrogenase (3-HBDH) with improved performance relative to the wild-type 3-HBDH, a nucleic acid encoding the mutant 3-HBDH, a cell comprising the mutant 3-HBDH or the nucleic acid, a method of determining the amount or concentration of 3-hydroxybutyrate in a sample, and a device for determining the amount or concentration of 3-hydroxybutyrate in a sample.
Inventors:
Daniella Beck
Mara Benitz-Durat
Peter Clutch
Thomas Streidel
Carina horn
Mara Benitz-Durat
Peter Clutch
Thomas Streidel
Carina horn
Application Number:
JP2018560256A
Publication Date:
January 05, 2022
Filing Date:
February 09, 2017
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C12N15/53; C12M1/34; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/04; C12Q1/32
Domestic Patent References:
| JP11318438A | ||||
| JP2016502656A | ||||
| JP2003339385A | ||||
| JP2011152094A |
Foreign References:
| US20100268043 |
Other References:
Accession No. A0A0N9NPT3, Confluentimicrobium sp. EMB200-NS6, 20-JAN-2016, entry version 1, Jin H.M., Jeong H.I., Kim K.H., Jeon C.O.,Database UniProt/Swisss-Prot[online],2016年01月20日,https://www.uniprot.org/uniprot/A0A0N9NPT3.txt?version=1
Accession No. A0A0D6B253, Rhodobacter sulfidophilus, 09-DEC-2015, entry version 5. , Nagao N.,Database UniProt/Swisss-Prot[online],2015年12月09日,https://www.uniprot.org/uniprot/A0A0D6B253.txt?version=5
Cloning and functional expression of the D-β-hydroxybutyrate dehydrogenase gene of Rhodobacter sp. DSMZ 12077.,Applied Microbiology and Biotechnology,1999年
Accession No. Q9XDL3, Rhodobacter sp. DSM 12077, 09-DEC-2015, entry version 58., Krueger K., Lang G., Engel A.M.,Database UniProt/Swisss-Prot[online],2015年12月09日,https://www.uniprot.org/uniprot/Q9XDL3.txt?version=58
Accession No. A0A0D6B253, Rhodobacter sulfidophilus, 09-DEC-2015, entry version 5. , Nagao N.,Database UniProt/Swisss-Prot[online],2015年12月09日,https://www.uniprot.org/uniprot/A0A0D6B253.txt?version=5
Cloning and functional expression of the D-β-hydroxybutyrate dehydrogenase gene of Rhodobacter sp. DSMZ 12077.,Applied Microbiology and Biotechnology,1999年
Accession No. Q9XDL3, Rhodobacter sp. DSM 12077, 09-DEC-2015, entry version 58., Krueger K., Lang G., Engel A.M.,Database UniProt/Swisss-Prot[online],2015年12月09日,https://www.uniprot.org/uniprot/Q9XDL3.txt?version=58
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Hidena Tsuda
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Hidena Tsuda