Title:
アジュバントとしてのコレラホロトキシンの突然変異形
Document Type and Number:
Japanese Patent JP2004535187
Kind Code:
A
Abstract:
Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.
Inventors:
Green, blues ray
Holmes, Randall Kay
The Jobbling, Michael Gee
Zoo, Douchi Young
Holmes, Randall Kay
The Jobbling, Michael Gee
Zoo, Douchi Young
Application Number:
JP2003501410A
Publication Date:
November 25, 2004
Filing Date:
June 05, 2002
Export Citation:
Assignee:
Weiss Holding Corporation
The Regents of the University of Colorado
The Regents of the University of Colorado
International Classes:
C12N15/09; A61K39/00; A61K39/002; A61K39/008; A61K39/02; A61K39/095; A61K39/102; A61K39/12; A61K39/245; A61K39/35; A61K39/39; A61P35/00; C07K14/185; C07K14/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; (IPC1-7): C12N15/09; A61K39/00; A61K39/002; A61K39/008; A61K39/02; A61K39/095; A61K39/102; A61K39/12; A61K39/245; A61K39/35; A61K39/39; C07K14/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Attorney, Agent or Firm:
Heikichi Odashima