アジュバントとしてのコレラホロトキシンの突然変異形

Japanese Patent JP2005508143

A

Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.

Green, blues ray
Holmes, Randall Kay
The Jobbling, Michael Gee
Zoo, Douchi Young

JP2003501411A

March 31, 2005

June 05, 2002

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Weiss Holding Corporation
Government of the United States of America as Represented by the Uniformed Services, University of the Health Sciences

A61K39/00; A61K39/002; A61K39/008; A61K39/015; A61K39/02; A61K39/04; A61K39/05; A61K39/07; A61K39/08; A61K39/085; A61K39/09; A61K39/095; A61K39/10; A61K39/102; A61K39/106; A61K39/108; A61K39/112; A61K39/118; A61K39/12; A61K39/125; A61K39/13; A61K39/145; A61K39/15; A61K39/155; A61K39/165; A61K39/175; A61K39/20; A61K39/205; A61K39/21; A61K39/215; A61K39/23; A61K39/235; A61K39/245; A61K39/255; A61K39/265; A61K39/29; A61K39/35; A61K39/39; A61P35/00; C07K14/185; C07K14/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/02; (IPC1-7): C12N15/09; A61K39/00; A61K39/002; A61K39/008; A61K39/015; A61K39/02; A61K39/04; A61K39/05; A61K39/07; A61K39/08; A61K39/085; A61K39/09; A61K39/095; A61K39/10; A61K39/102; A61K39/106; A61K39/108; A61K39/112; A61K39/118; A61K39/12; A61K39/125; A61K39/13; A61K39/145; A61K39/15; A61K39/155; A61K39/165; A61K39/175; A61K39/20; A61K39/205; A61K39/21; A61K39/215; A61K39/23; A61K39/235; A61K39/245; A61K39/255; A61K39/265; A61K39/29; A61K39/35; A61K39/39; C07K14/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02

Heikichi Odashima

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