Title:
Mutant interleukin-2 polypeptide
Document Type and Number:
Japanese Patent JP6155300
Kind Code:
B2
Abstract:
The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
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Inventors:
Ast, oliver
Bullenker, Peter
Fly Moser-Grund Showbar, Anne
Herter, Sylvia
Hofer, Thomas Wu.
Hosse, Ralph
Klein, Christian
Messner, Eckhard
Nicolini, Valeria F.
Umagna, Pablo
Bullenker, Peter
Fly Moser-Grund Showbar, Anne
Herter, Sylvia
Hofer, Thomas Wu.
Hosse, Ralph
Klein, Christian
Messner, Eckhard
Nicolini, Valeria F.
Umagna, Pablo
Application Number:
JP2015102866A
Publication Date:
June 28, 2017
Filing Date:
May 20, 2015
Export Citation:
Assignee:
Roche Glicart Age
International Classes:
C12N15/09; A61K38/20; A61K39/395; A61P35/00; A61P37/04; C07K14/55; C07K16/30; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12P21/08
Domestic Patent References:
| JP2009542592A |
Other References:
Cellular Immunology,1993年,147, 1,p.167-179
PNAS,1991年,Vol.88, No.11,p.4636-4640
PNAS,1991年,Vol.88, No.11,p.4636-4640
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation