変異ERαおよび転写活性化の試験系

Japanese Patent JP4742483

B2

The present invention provides in general an artificial cell, an isolated mutant ERalpha, an isolated polynucleotide encoding the mutant ERalpha, a method for quantitatively analyzing an activity for transactivation of a reporter gene by a test ERalpha, a method for screening a mutant ligand dependent transcriptional factor, a method for evaluating an activity for transactivation of a reporter gene by a test ERalpha, a method for screening a compound useful for treating a disorder of a mutant ERalpha, a pharmaceutical agent useful for treating an estrogenic disorder of a mutant ERalpha, use of the mutant ERalpha, a method for diagnosing a genotype of a polynucleotide encoding a test ERalpha, a method for diagnosing a genotype of a polynucleotide encoding a test ERalpha and a method for diagnosing a phenotype of a test ERalpha.

Koichi Saito
Oe Shihisa
Hideo Sato

JP2001543602A

August 10, 2011

December 01, 2000

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Sumitomo Chemical Co., Ltd.

C12N15/09; G01N33/50; A61K45/00; A61P43/00; C07K14/72; C12N1/19; C12N5/10; C12N7/00; C12Q1/68; G01N33/15

WO1987005049A1

The EMBO Journal,1990, Vol.9, No.9, pp.2811-2818
Journal of Steroid Biochemistry and Molecular Biology,1997, Vol.62, No.2/3, pp.173-184
Molecular Endocrinology, 1996, Vol.10, pp.230-242
Japanese Journal of Cancer Research,1998, Vol.89, pp.27-32
Journal of the National Cancer Institute,1995, Vol.87, No.6, pp.446-451
MCDONNELL D P,BIO/TECHNOLOGY,米国,NATURE PUBLISHING CO,1993年11月 1日,V11,P1256-1261

Toru Nakayama

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