Title:
ヒトパピローマウイルスタイプ５８のＬ１タンパク質の突然変異
Document Type and Number:
Japanese Patent JP6958818
Kind Code:
B2
Abstract:
Provided are a mutated HPV58 L1 protein or a variant thereof, a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein or a variant thereof and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types, and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. The invention further relates to the use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.
Inventors:
Lee Shao Way
Lee Chi High
Song Shuo
Falcon butterfly
Coin
Xia Nin Xiao
Lee Chi High
Song Shuo
Falcon butterfly
Coin
Xia Nin Xiao
Application Number:
JP2018548263A
Publication Date:
November 02, 2021
Filing Date:
December 02, 2016
Export Citation:
Assignee:
XIAMEN UNIVERSITY
International Classes:
C07K14/025; A61K35/76; A61K38/16; A61K39/12; A61P15/00; A61P31/20; A61P35/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/01; C12N15/37; C12N15/63; C12P21/02
Foreign References:
| US20130315943 | ||||
| US20050058988 |
Other References:
Vaccine,2014年,Vol. 32,pp. 6548-6555
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
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