Title:
マイコプラズマ由来リポタンパク/リポペプチド不応答性モデル非ヒト動物
Document Type and Number:
Japanese Patent JP4100595
Kind Code:
B2
Abstract:
An object of the present invention is to provide a non-human animal model unresponsive to a mycoplasma-derived lipoprotein/lipopeptide, and a method for screening an inhibitor or a promoter for a response to a mycoplasma-derived lipoprotein with the use of the non-human animal model. A non-human animal model whose function of a gene that encodes a protein such as TLR6 that specifically recognizes a mycoplasma-derived lipoprotein is deficient on its chromosome, for example, a TLR6 knockout mouse, is generated. With the use of the non-human animal model unresponsive to a mycoplasma-derived lipoprotein or an immune cell such as a macrophage derived from the non-human animal model, a subject material and a mycoplasma-derived lipoprotein, a response to a mycoplasma-derived lipoprotein in the non-human animal model or the immune cell is measured/evaluated, and then an inhibitor or a promoter for a response to that is screened.
Inventors:
Shizuo Akira
Osamu Takeuchi
Osamu Takeuchi
Application Number:
JP2000232451A
Publication Date:
June 11, 2008
Filing Date:
July 31, 2000
Export Citation:
Assignee:
Japan Science and Technology Agency
International Classes:
A01K67/027; C07K7/08; C07K14/705; C12N5/10; C12N15/09; C12N15/85; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566; G01N33/569; G01N33/68
Domestic Patent References:
| JP2000128900A |
Foreign References:
| WO2000041561A2 |
Other References:
Immunity,Vol.11,No.4(1999)p.443-451
Gene,Vol.231,No.1-2(1999)p.59-65
Gene,Vol.231,No.1-2(1999)p.59-65
Attorney, Agent or Firm:
Masaki Hirota