Title:
11-ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのN-2アダマンタニル-2-フェノキシ-アセトアミド誘導体
Document Type and Number:
Japanese Patent JP5208505
Kind Code:
B2
Abstract:
the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z represents O, S, NR6, SO or SO2; R1 represents hydrogen, cyano, hydroxy, or C1-4alkyl optionally substituted with halo, R2 represents hydrogen, C1-4alkyl, or C1-4alkyloxy-; R3 represents hydrogen, C1-4alkyl, C1-4alkyloxy- or R3 combined with R2 form together a divalent radical selected from the group consisting of —O—CH2— (a), —NR7—CH2— (b), —(CR8R9)m- (c) and —CR10═ (d) wherein m represents 1 or 2 and R7, R8, R9 and R10 are each independently selected from hydrogen or C1-4alkyl; R4 represents hydrogen, halo, hydroxy, cyano, amino, NR11R12, C1-4alkyloxy- optionally substituted with one or where possible two or three substituents selected from hydroxy and halo or R4 represents C1-4alkyl optionally substituted with one or where possible two or three substituents selected from hydroxy and halo; R5 represents hydrogen, halo, cyano, amino, phenyl, hydroxy, C1-4alkyloxycarbonyl, hydroxycarbonyl, NR13R14 or C1-4alkyl substituted with one or more substituents selected from hydroxycarbonyl, phenyl, C1-4alkyloxy or NR15R16; R6 represents hydrogen; R11 and R12 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-; R13 and R14 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-; R15 and R16 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-; R17 and R18 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-.
Inventors:
Yaroskova, Ribze
Linders, Johannes Theodorus Maria
Van der Beken, Luis Joseph Elisabeth
Willemsens, Gustav Henri Maria
Bissyoff, Francois Paul
Linders, Johannes Theodorus Maria
Van der Beken, Luis Joseph Elisabeth
Willemsens, Gustav Henri Maria
Bissyoff, Francois Paul
Application Number:
JP2007528861A
Publication Date:
June 12, 2013
Filing Date:
August 26, 2005
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07C235/14; A61K31/16; A61K31/164; A61K31/18; A61K31/21; A61K31/27; A61K31/343; A61K31/357; A61K31/4015; A61K31/421; A61K31/4453; A61K31/5375; A61K31/538; A61K45/00; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/12; A61P19/10; A61P25/00; A61P25/28; A61P27/06; A61P43/00; C07C237/10; C07C271/24; C07C271/38; C07C275/26; C07C307/08; C07C311/07; C07C311/20; C07C317/44; C07C323/62; C07D207/27; C07D263/22; C07D265/36; C07D295/14; C07D295/22; C07D307/85; C07D311/66; C07D319/16
Domestic Patent References:
| JP2001261663A | ||||
| JP10504545A | ||||
| JP2003510331A | ||||
| JP2001524468A |
Foreign References:
| WO2004056744A1 | ||||
| WO2004089415A2 | ||||
| WO2004089416A2 | ||||
| WO2006002361A2 | ||||
| WO2004056745A2 | ||||
| WO2004089470A2 |
Other References:
SABRI S S,JOURNAL OF CHEMICAL AND ENGINEERING DATA,米国,AMERICAN CHEMICAL SOCIETY,1984年,V29 N2,P229-231
AVDYUNINA,N.I.,KHIMIKO-FARMATSETIVICHESKII ZHURNAL,1988年,V22 N7,P819-822
REGISTRY(STN)[online],2001年4月25日(検索日:2011年6月21日)CAS登録番号:332399-46-9
REGISTRY(STN)[online],2001年5月31日(検索日:2011年6月21日)CAS登録番号:339060-39-8
REGISTRY(STN)[online],2002年4月10日(検索日:2011年6月21日)CAS登録番号:405076-63-3
REGISTRY(STN)[online],2002年4月10日(検索日:2011年6月21日)CAS登録番号:405076-76-8
REGISTRY(STN)[online],2002年4月10日(検索日:2011年6月21日)CAS登録番号:405081-06-3
AVDYUNINA,N.I.,KHIMIKO-FARMATSETIVICHESKII ZHURNAL,1988年,V22 N7,P819-822
REGISTRY(STN)[online],2001年4月25日(検索日:2011年6月21日)CAS登録番号:332399-46-9
REGISTRY(STN)[online],2001年5月31日(検索日:2011年6月21日)CAS登録番号:339060-39-8
REGISTRY(STN)[online],2002年4月10日(検索日:2011年6月21日)CAS登録番号:405076-63-3
REGISTRY(STN)[online],2002年4月10日(検索日:2011年6月21日)CAS登録番号:405076-76-8
REGISTRY(STN)[online],2002年4月10日(検索日:2011年6月21日)CAS登録番号:405081-06-3
Attorney, Agent or Firm:
Patent business corporation Odashima patent office