To provide an HIV protease inhibitor existing in a virus over a long period and having low toxicity.
The compound obtained by chemical synthesis and expressed by formula (1) or its pharmacologically permissible salt is suitable for the treatment of a patient or a host infected with HIV virus. In the formula, E is carbon or nitrogen; Y is oxygen, substituted nitrogen, sulfur, selenium or two H atoms; A is a (substituted) carbocyclic or heterocyclic group; Q1 is a (substituted) carbocyclic group, heterocyclic group or aliphatic group; Q2 is OH, a halogen, an alkyl or the like; Q3 is selected from mercapto group, thioether group and amino group; and Q4 to Q8 are, if present, hydrogen, dioxide, hydroxylthioether, acyl, alkyl, arylheterocyclic group or the like.
Ishii Teiji
Yasushi Hayakawa