Title:
アテローム性動脈硬化および循環器疾患の治療のためのCETP阻害剤としてのN-((3-ベンジル)-2,2-(ビス-フェニル)-プロパン-1-アミン誘導体
Document Type and Number:
Japanese Patent JP5498168
Kind Code:
B2
Abstract:
Compounds of formula Ia and Ib wherein A, B, C, R1 and R14 are described herein.
Inventors:
Mark E Salvati
James A Johnson
Sue Ninnin
James A Johnson
Sue Ninnin
Application Number:
JP2009539455A
Publication Date:
May 21, 2014
Filing Date:
November 28, 2007
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07C211/52; A61K31/137; A61K31/165; A61K31/17; A61K31/18; A61K31/216; A61K31/27; A61K31/351; A61K31/36; A61K31/365; A61K31/397; A61K31/4045; A61K31/415; A61K31/42; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/505; A61K31/5375; A61P3/04; A61P3/06; A61P3/10; A61P7/00; A61P7/02; A61P9/00; A61P9/10; A61P9/12; A61P25/28; A61P43/00; C07C215/08; C07C215/76; C07C229/22; C07C233/18; C07C233/60; C07C271/16; C07C275/24; C07C307/06; C07C311/04; C07C311/17; C07C323/37; C07D205/08; C07D209/14; C07D213/38; C07D213/61; C07D213/64; C07D213/74; C07D231/12; C07D231/14; C07D231/16; C07D231/20; C07D239/42; C07D261/08; C07D295/12; C07D307/33; C07D309/04; C07D309/14; C07D317/46
Domestic Patent References:
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| JP11071350A | ||||
| JP2002097138A | ||||
| JP11130757A | ||||
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Foreign References:
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Other References:
DeVRIES,V.G. et al.,Potential Antiatherosclerotic agents. 6. Hypocholesterolemic trisubstituted urea analogues,JOURNAL OF MEDICINAL CHEMISTRY,1989年,V32 N10,P2318-2325
PERELMAN,M. and MIZSAK,S.,2,2,3-Triarylpropionitriles and related compounds as hypocholesterolemic agents,JOURNAL OF MEDICINAL CHEMISTRY,1963年 9月,V6,P533-538
LIU,W. et al.,Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis,Bioorganic and Medicinal Chemistry Letters,2005年,15(20),4574-4578
HOEFLE,M.L. et al.,Synthesis and antiarrhythmic activity of cis-2,6-dimethyl-α,α-diaryl-1-piperidinebutanols,JOURNAL OF MEDICINAL CHEMISTRY,1991年,V34 N1,P12-19
DeLUCCA,G.V. et al.,Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists,JOURNAL OF MEDICINAL CHEMISTRY,2002年,V45 N17,P3794-3804
NG,H.P. et al.,Discovery of Novel Non-Peptide CCR1 Receptor Antagonists,JOURNAL OF MEDICINAL CHEMISTRY,1999年,V42 N22,P4680-4694
BIGLER,A.J. et al.,Novel lipophilic nitrosoureas,INSERM Symposium ,1981年,19(Nitrosoureas Cancer Treat.),113-22
PERELMAN,M. and MIZSAK,S.,2,2,3-Triarylpropionitriles and related compounds as hypocholesterolemic agents,JOURNAL OF MEDICINAL CHEMISTRY,1963年 9月,V6,P533-538
LIU,W. et al.,Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis,Bioorganic and Medicinal Chemistry Letters,2005年,15(20),4574-4578
HOEFLE,M.L. et al.,Synthesis and antiarrhythmic activity of cis-2,6-dimethyl-α,α-diaryl-1-piperidinebutanols,JOURNAL OF MEDICINAL CHEMISTRY,1991年,V34 N1,P12-19
DeLUCCA,G.V. et al.,Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists,JOURNAL OF MEDICINAL CHEMISTRY,2002年,V45 N17,P3794-3804
NG,H.P. et al.,Discovery of Novel Non-Peptide CCR1 Receptor Antagonists,JOURNAL OF MEDICINAL CHEMISTRY,1999年,V42 N22,P4680-4694
BIGLER,A.J. et al.,Novel lipophilic nitrosoureas,INSERM Symposium ,1981年,19(Nitrosoureas Cancer Treat.),113-22
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka