Title:
HIVインテグラーゼ阻害剤として有用であるN-ベンジル-3,4-ジヒドロキシピリジン-2-カルボキサミド及びN-ベンジル-2,3-ジヒドロキシピリジン-4-カルボキサミド化合物
Document Type and Number:
Japanese Patent JP2007519735
Kind Code:
A
Abstract:
N-Benzyl-dihydroxypyridine carboxamide compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dihydroxypyridine carboxamides are of Formula (I) wherein Q is Formula (II) or Formula (III); T is Formula (IV); and R1, R2, X1,X2,X3, and Y1 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
Inventors:
The Johns, Philip
Williams, Peter Day
Moriset, Machine M
Kuo, Michelle Sparks
Batka, Joseph P
Williams, Peter Day
Moriset, Machine M
Kuo, Michelle Sparks
Batka, Joseph P
Application Number:
JP2006551441A
Publication Date:
July 19, 2007
Filing Date:
January 26, 2005
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D213/81; A61K31/44; A61K31/4409; A61K31/4412; A61K31/4436; A61K31/4439; A61K31/444; A61K31/4725; A61K31/496; A61K31/497; A61K31/506; A61K31/5377; A61K45/00; A61P31/18; A61P43/00; C07D211/74; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D409/04; C07D413/04; C07D413/12; C07D417/12
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura