Title:
N-METHYL, N-(6-(METHOXY)PYRIDAZIN-3-YL) AMINE DERIVATIVES AS AUTOTAXIN (ATX) MODULATORS FOR THE TREATMENT OF INFLAMMATORY AIRWAY OR FIBROTIC DISEASES
Document Type and Number:
Japanese Patent JP2023116436
Kind Code:
A
Abstract:
To provide means for treating inflammatory airway or fibrotic diseases.SOLUTION: The present invention relates to N-methyl, N-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases such as e.g. idiopathic lung disease (IPF) or systemic sclerosis (SSc). The present description discloses exemplary compounds (e.g. pages 57 to 75; examples 1.1 to 5) as well as relevant biological data thereof (e.g. pages 15 to 21, tables 1 to 9). An exemplary compound is e.g. 1-(6-(4-(((6-((6-(trifluoromethyl) pyridin-3-yl)methoxy)pyridazin-3-yl)amino)methyl)phenyl)-2,6- diazaspiro[3.3]heptan-2-yl)ethan-1-one (example 1.1).SELECTED DRAWING: None
Inventors:
CHRISTIAN ANDREAS KUTTRUFF
TOM BRETSCHNEIDER
CEDRICKX GODBOUT
HANNES FIEPKO KOOLMAN
DOMINIC MARTYRES
GERALD JUERGEN ROTH
TOM BRETSCHNEIDER
CEDRICKX GODBOUT
HANNES FIEPKO KOOLMAN
DOMINIC MARTYRES
GERALD JUERGEN ROTH
Application Number:
JP2023069392A
Publication Date:
August 22, 2023
Filing Date:
April 20, 2023
Export Citation:
Assignee:
BOEHRINGER INGELHEIM INT
International Classes:
C07D401/12; A61K31/501; A61K31/55; A61P11/00; A61P29/00; A61P43/00; C07D401/14; C07D405/14; C07D487/04; C07D487/08; C07D487/10
Attorney, Agent or Firm:
Shinichiro Tanaka
Hiroyuki Suda
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Nanae Matsuda
Takamitsu Hoshino
Hiroyuki Suda
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Nanae Matsuda
Takamitsu Hoshino