To obtain a new N-acylpiperazine derivative having an antiulcer action and an antibacterial action against Helicobacter pylori and useful as an antibacterial agent, an antiulcer agent, etc., for preventing generation and curing, etc., of ulcer, comprising a specific N-acylpiperazine derivative.
This new N-acylpiperazine derivative (salt) is expressed by formula I {R1 is a pyridylcarbonyloxy lower alkyl, a benzylamino lower alkyl, benzyl, carbamoyl, pyridyl or diphenylmethyl; R2 is a lower alkyl or a lower alkoxy; (n) is an integer of 0 to 2; R3 is H, an alkenyl or benzyl; (m) is an integer of 1 to 3} and is useful as an antibacterial agent, an antiulcer agent, etc., with having an antiulcer action and an antibacterial action against Helicobacter pylori. The compound is obtained by reacting benzoic acid having a substituting group expressed by formula II with N-substituted piperazine of formula III.
SATO FUMITAKA
FUKUNISHI HIROTADA
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