Title:
N-アシルスルホンアミド系アポトーシス促進剤
Document Type and Number:
Japanese Patent JP5086513
Kind Code:
B2
Abstract:
N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
Inventors:
McClellan, William
Ost, Torsten
Brunco, Milan
One, seal
Audieri, David The Ray
Bow Meister, Stephen A
D. Kuman, Daniel A.
Dane, Hong
Dinges, Jurgen
Huesik, Stephen Davryu
Hydoku, Philip Jei
Kunzer, Aaron Earl
Nettesseheim, David G
Petros, Andrew M
Rosenberg, Saul H
Cien, Wan
Thomas, Sheila A
Went, Michael Day
Ost, Torsten
Brunco, Milan
One, seal
Audieri, David The Ray
Bow Meister, Stephen A
D. Kuman, Daniel A.
Dane, Hong
Dinges, Jurgen
Huesik, Stephen Davryu
Hydoku, Philip Jei
Kunzer, Aaron Earl
Nettesseheim, David G
Petros, Andrew M
Rosenberg, Saul H
Cien, Wan
Thomas, Sheila A
Went, Michael Day
Application Number:
JP2002529049A
Publication Date:
November 28, 2012
Filing Date:
September 20, 2001
Export Citation:
Assignee:
ABBOTT LABORATORIES
International Classes:
C07C311/46; A61K31/18; A61K31/428; A61K31/63; A61K31/635; A61P9/10; A61P25/16; A61P25/28; A61P29/00; A61P31/12; A61P31/18; A61P35/00; A61P37/02; C07C311/51; C07C317/28; C07C323/12; C07C323/17; C07C323/25; C07C323/30; C07C323/37; C07C323/43; C07C323/44; C07C323/48; C07C323/58; C07C323/60; C07D203/10; C07D205/04; C07D205/12; C07D207/09; C07D207/24; C07D207/404; C07D209/08; C07D209/52; C07D209/54; C07D209/96; C07D211/14; C07D211/44; C07D211/70; C07D211/74; C07D213/56; C07D213/61; C07D213/64; C07D213/69; C07D213/70; C07D213/71; C07D215/14; C07D215/227; C07D215/38; C07D215/48; C07D217/04; C07D221/20; C07D231/12; C07D233/60; C07D235/08; C07D235/26; C07D241/08; C07D241/16; C07D249/04; C07D263/32; C07D263/56; C07D263/58; C07D277/62; C07D277/64; C07D295/13; C07D295/155; C07D295/16; C07D295/185; C07D295/20; C07D295/205; C07D295/215; C07D295/26; C07D307/14; C07D317/54; C07D333/28; C07D333/68; C07D333/70; C07D401/06; C07D401/12; C07D405/04; C07D405/06; C07D417/12; C07D451/02; C07D491/107; C07D207/40; C07D215/22
Domestic Patent References:
| JP2001294581A | ||||
| JP60152401A | ||||
| JP10120645A | ||||
| JP9311401A | ||||
| JP62161761A | ||||
| JP62181261A |
Other References:
DUBINA,V.L. et al,N - (Arylchloromethylene)arenesulfonamides. I. Synthesis, study of hydrolysis, and their reactions with amines,Zhurnal Organicheskoi Khimii,1966年,Vol.2, No.10,p.1841-5
KREMLEV,M.M. et al,Studies on arenesulfonylamides. LXXXIX. Arenesulfonylamidation of aromatic aldehydes and formamides,Zhurnal Organicheskoi Khimii,1977年,Vol.13, No.1,p.134-138
ENGLISH,J.P. et al,Chemotherapy. XIV. Antimalarials. The synthesis of substituted metanilamides and related compounds,Journal of the American Chemical Society,1946年,Vol.68,p.1039-49
PLOTNIKOVA,M.T. et al,Arenesulfonamides. LXXX. Aroylarenesulfonamides,Voprosy Khimii i Khimicheskoi Tekhnologii,1974年,Vol.33,p.20-5
SRIVASTAVA,A.K. et al,Studies in organic fluorine compounds. Part V. Synthesis of diaryl sulfonates and N-acyl arylsulfonamides as potential fungicides,Agricultural and Biological Chemistry,1976年,Vol.40, No.4,p.805-6
HABIB,O.M. et al,Synthesis of some new N-aroylsulfonamides and sulfonate esters of xylenesulfonic acids of potential biological activity,Hungarian Journal of Industrial Chemistry,1986年,Vol.14, No.4,p.477-83
KREMLEV,M.M. et al,Studies on arenesulfonylamides. LXXXIX. Arenesulfonylamidation of aromatic aldehydes and formamides,Zhurnal Organicheskoi Khimii,1977年,Vol.13, No.1,p.134-138
ENGLISH,J.P. et al,Chemotherapy. XIV. Antimalarials. The synthesis of substituted metanilamides and related compounds,Journal of the American Chemical Society,1946年,Vol.68,p.1039-49
PLOTNIKOVA,M.T. et al,Arenesulfonamides. LXXX. Aroylarenesulfonamides,Voprosy Khimii i Khimicheskoi Tekhnologii,1974年,Vol.33,p.20-5
SRIVASTAVA,A.K. et al,Studies in organic fluorine compounds. Part V. Synthesis of diaryl sulfonates and N-acyl arylsulfonamides as potential fungicides,Agricultural and Biological Chemistry,1976年,Vol.40, No.4,p.805-6
HABIB,O.M. et al,Synthesis of some new N-aroylsulfonamides and sulfonate esters of xylenesulfonic acids of potential biological activity,Hungarian Journal of Industrial Chemistry,1986年,Vol.14, No.4,p.477-83
Attorney, Agent or Firm:
Yoshio Kawaguchi
Mitsuru Inoue
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuru Inoue
Akio Ichiiri
Makoto Ono
Katsuma Osaki