Title:
N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS
Document Type and Number:
Japanese Patent JP2013144686
Kind Code:
A
Abstract:
To provide N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury.
This invention relates to novel N-hydroxysulfonamide derivatives represented by chemical formula (I). The novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
Inventors:
TOSCANO JOHN P
BROOKFIELD FREDERICK ARTHUR
COHEN ANDREW D
COURTNEY STEPHEN MARTIN
FROST LISA MARIE
KALISH VINCENT JACOB
BROOKFIELD FREDERICK ARTHUR
COHEN ANDREW D
COURTNEY STEPHEN MARTIN
FROST LISA MARIE
KALISH VINCENT JACOB
Application Number:
JP2013032658A
Publication Date:
July 25, 2013
Filing Date:
February 21, 2013
Export Citation:
Assignee:
JOHNS HOPKINS UNIV SCHOOL OF MEDICINE
CARDIOXYL PHARMACEUTICALS INC
CARDIOXYL PHARMACEUTICALS INC
International Classes:
C07C311/48; C07C317/14; C07C321/28; C07C321/30; C07D215/16; C07D231/18; C07D261/10; C07D307/82; C07D333/34; C07D333/62; A61K31/343; A61K31/381; A61K31/415; A61K31/42; A61K31/47; A61P3/06; A61P3/10; A61P7/10; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00
Domestic Patent References:
| JPH01221371A | 1989-09-04 | |||
| JPH04321671A | 1992-11-11 | |||
| JP2008543947A | 2008-12-04 | |||
| JP2003519134A | 2003-06-17 |
Foreign References:
| US3751255A | 1973-08-07 |
Other References:
J. MED. CHEM., vol. 44, JPN6014023332, 2001, pages 1016, ISSN: 0002827329
Attorney, Agent or Firm:
Kiyoji Kuzuwa