Title:
N-HYDROXYUREA DERIVATIVE
Document Type and Number:
Japanese Patent JP3558154
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new compound, having two actions of inhibiting actions on a lipoxygenease and inhibiting actions on a thromboxane synthase and useful for treating and mitigating allergic diseases, etc.
SOLUTION: This compound is represented by formula I (one of R1 to R3 is 3-pyridyl, etc., and the others are H, a 1-8C alkyl, etc.; R4 is H or a lower alkyl; R5 is H, a lower alkyl, etc.; A is a bond, a 1-20C alkylene, etc.), e.g. N-hydroxy-N-[5-[1-(3-pyridylmethyl)indolyl]]methylurea. The compound represented by formula I is obtained by reacting an alcohol represented by formula II (Q is represented by formula III) with N,O-bis(tert-butoxycarbonyl) hydroxylamine under conditions of the Mitsunobu reaction, providing a compound represented by formula IV in which the N and O are protected, then hydrolyzing the resultant compound with an acid, affording a compound represented by formula V and further reacting the compound represented by formula V with trimethylsilyl isocyanate.
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Inventors:
Michika Takano
Toshiya Komatsu
Yoshikazu Kawahara
Toshiya Komatsu
Yoshikazu Kawahara
Application Number:
JP35401897A
Publication Date:
August 25, 2004
Filing Date:
December 09, 1997
Export Citation:
Assignee:
Nikken Chemical Co., Ltd.
International Classes:
C07D401/04; A61K31/44; A61K31/4427; A61K31/4439; A61P3/02; A61P29/00; A61P37/08; C07D401/06; (IPC1-7): C07D401/04; A61K31/4439; C07D401/06
Domestic Patent References:
| JP3148272A | ||||
| JP6500557A |