Title:
FSADのためのNEP阻害剤としてのN-フェンプロピルシクロペンチル-置換グルタルアミド誘導体
Document Type and Number:
Japanese Patent JP4018545
Kind Code:
B2
Abstract:
The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R<1> is optionally substituted C1-6alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C1-6alkoxy, -NR2 R<3> or - NR<4>SO2R<5>; X is the linkage -(CH2)n- or -(CH2)q-O- (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by C1-4alkoxy; hydroxy; hydroxy(C1-3alkyl); C3-7cycloalkyl; carbocyclyl; heterocyclyl; or by C1-4alkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6, or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two R<8> groups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5- or 6-membered carbocyclic or heterocyclyic ring.
Inventors:
Challenger, Stephen
Cook, Andrew Simon
Gilmore, Adam Thomas
Donald Stuart, Middleton
Pride, david cameron
Alan Stove
Cook, Andrew Simon
Gilmore, Adam Thomas
Donald Stuart, Middleton
Pride, david cameron
Alan Stove
Application Number:
JP2002577770A
Publication Date:
December 05, 2007
Filing Date:
March 18, 2002
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
C07C233/58; C07D317/46; A61K31/165; A61K31/19; A61K31/195; A61K31/275; A61K31/277; A61K31/335; A61K31/343; A61K31/353; A61K31/357; A61K31/36; A61K31/40; A61K31/41; A61K31/416; A61K31/435; A61K31/4402; A61K31/4418; A61K31/4535; A61K31/47; A61K31/519; A61K31/565; A61K31/566; A61K31/568; A61K45/00; A61P15/00; A61P15/10; A61P43/00; C07C233/59; C07C233/60; C07C235/40; C07C235/82; C07C255/60; C07C323/40; C07D213/55; C07D215/12; C07D231/56; C07D307/79; C07D307/81; C07D311/04; C07D311/58; C07D311/74; C07D317/52; C07D317/62; C07D319/12; C07D319/18; C07D319/20; C07D213/40; A61K; A61P; C07C; C07D
Domestic Patent References:
| JP8509988A | ||||
| JP2022256A | ||||
| JP5501111A | ||||
| JP2004502670A | ||||
| JP5502023A |
Other References:
Tetrahedron Letters,1999年,Vol.40, No.11,p.2187-2190
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama
Takashi Ishida
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama