N-SUBSTITUTED ARYLALKYL-AND-ARYLALKYLENE-AMINO HETEROCYCLIC COMPOUND AS CARDIOVASCULAR DRUG,ANTIHISTAMIC DRUG AND SECRETION INHIBITIVE DRUG

Japanese Patent JPS62169763

A

(1) N-Aryl-pyrrolidine, -piperidine and -homopiperidine derivs. of formula (I) and their acid-addn. and quat. salts and their hydrates and alcoholates are new. p = 0, 1 or 2; A = H, OR1, CN, CONR1R2, COR1, COOR1, OCOR1, CH2OR1 or CH2NR1R2; m = 0-6; Q = CH, CH2 or CH(OH); d, n = 0 or 1 and the dotted lines are opt. double bonds; Ar = X,Y,ZC6H2, pyridyl, thienyl, furyl or naphthyl; R = Ar gp., X,Y,ZC6H2CH2, cycloalkyl or 1-8C alkyl; D = Ar gp., quinolyl, Ar(CH2)5 or a gp. of formulae (II)-(IV). In (III) when X = H, bond a may be a single bond; s = 1-4; t = 0, 1 or 2; X,Y,Z = H, 1-8C alkyl, halogen, NO2, OR1, COR1, CF3, CN, CONR1R1, NR1R1, COOR1, SO2R2, SR2, SOR2, NR1-COR2, CH2COOM, SO2NR1R2, NR1-SO2Me, NR1-CONR1R2 or NR1-COOR2; B = O, S, SO, SO2, NR1 or N-COOR1; z = 0 or 1, but it is not 0 when n = 0 and D = opt. substd. Ph, or (A)d = H or CN or aminocarbonyl, or a there is a double bond between the alpha C atom and a C atom of the pyrrolidino etc. ring; R1 = H, 1-8C alkyl, Ph or Ph-(1-8C)alkyl; R2 = 1-8C alkyl, Ph or Ph-(1-8C) alkyl; M = metal ion. (2) Pharm. compsn. for use as a Ca antagonist in the treatment of hypertension comprises a cpd. (I) but without the proviso about (B)z. (3) Pharm. compsn. for use as an antihistamine or for the redn. of gastric secretion comprises a cpd. (I) but without the proviso about (B)z.

JIEEMUSU ROBAATO SHIYANKURIN J
ANTONII JIYOOJI PUROAKINSU

JP16967386A

July 25, 1987

July 18, 1986

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ROBINS CO INC A H

A61K31/395; A61K31/40; A61K31/44; A61K31/4402; A61K31/4409; A61K31/4418; A61K31/4427; A61K31/443; A61K31/4433; A61K31/451; A61K31/47; A61K31/55; A61P1/04; A61P3/00; A61P9/08; A61P9/10; A61P9/12; A61P37/08; A61P43/00; C07C41/00; C07C43/225; C07C49/84; C07C67/00; A61K31/445; C07C211/22; C07C253/00; C07C255/35; C07C255/54; C07D207/00; C07D207/08; C07D207/09; C07D207/20; C07D207/32; C07D207/323; C07D207/325; C07D207/33; C07D207/335; C07D207/337; C07D207/46; C07D207/48; C07D207/50; C07D211/00; C07D211/08; C07D211/10; C07D211/12; C07D211/14; C07D211/18; C07D211/20; C07D211/22; C07D211/26; C07D211/28; C07D211/32; C07D211/34; C07D211/46; C07D211/62; C07D211/68; C07D211/70; C07D211/82; C07D211/92; C07D211/94; C07D211/96; C07D211/98; C07D213/16; C07D213/30; C07D215/26; C07D223/00; C07D223/04; C07D227/04; C07D311/24; C07D319/00; C07D401/00; C07D401/06; C07D401/10; C07D401/12; C07D401/14; C07D405/00; C07D405/04; C07D405/06; C07D405/12; C07D405/14; C07D409/12; C07D409/14; A61K; C07D; (IPC1-7): A61K31/445; C07/; C07C43/225; C07C49/84; C07C79/35; C07C103/38; C07C121/66; C07C121/75; C07C125/06; C07C127/19; C07C147/06; C07C147/14; C07D207/08; C07D211/12; C07D211/14; C07D211/18; C07D211/22; C07D211/34; C07D211/46; C07D211/70; C07D401/06; C07D401/12; C07D405/06; C07D405/12

JP33007630A
JPS6287585A	1987-04-22
JPS62148468A	1987-07-02

Kyozo Yuasa (3 outside)

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