Title:
Ｎ−２置換プリン類
Document Type and Number:
Japanese Patent JP3535519
Kind Code:
B2
Abstract:
This invention presents novel purine-based compounds for inclusion into oligonucleotides. The compounds of the invention, when incorporated into oligonucleotides are especially useful as "antisense" agents-agents that are capable of specific hybridization with a nucleotide sequence of an RNA. Oligonucleotides are used for a variety of therapeutic and diagnostic purposes, such as treating diseases, regulating gene expression in experimental systems, assaying for RNA and for RNA products through the employment of antisense interactions with such RNA, diagnosing diseases, modulating the production of proteins, and cleaving RNA in site specific fashions. The compounds of the invention include novel heterocyclic bases, nucleosides, and nucleotides. When incorporated into oligonucleotides, the compounds of the invention can be useful for modulating the activity of RNA.
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Inventors:
クック，フィリップ・ダン
マノハラン，ムシア
ラマサミー，カンダ・エス
マノハラン，ムシア
ラマサミー，カンダ・エス
Application Number:
JP51525895A
Publication Date:
June 07, 2004
Filing Date:
November 29, 1994
Export Citation:
Assignee:
アイシス・ファーマシューティカルス・インコーポレーテッド
International Classes:
A61K31/415; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7076; A61K31/708; A61K31/7088; C07D473/16; A61K47/48; A61P31/12; C07D473/18; C07D487/04; C07H19/04; C07H19/06; C07H19/10; C07H19/16; C07H19/167; C07H19/173; C07H19/20; C07H21/00; C07H21/02; C07H21/04; C07H23/00; C07J43/00; C12N9/02; C12N15/113; C12Q1/68; A61K38/00; A61K48/00; (IPC1-7): C07H21/02; A61K31/7115; C07D473/16; C07H19/167; C07H19/173; C07H21/04
Attorney, Agent or Firm:
社本 一夫 （外５名）