Title:
NAALADase INHIBITOR USEFUL AS PHARMACEUTICAL COMPOUND AND COMPOSITION
Document Type and Number:
Japanese Patent JP2010001312
Kind Code:
A
Abstract:
To provide a compound and a pharmaceutical composition comprising the same for treating glutamate abnormalities, compulsive disorder, prostate disease, pain and diabetic neuropathy.
There are provided the N-acetylated alpha-linked acidic dipeptidase (NAALADase) enzyme activity inhibitors having a specific structure, pharmaceutical composition comprising such inhibitor, and the method of their use.
Inventors:
JACKSON PAUL F
MACLIN KEITH M
WANG ERIC
SLUSHER BARBARA
LAPIDUS RENA S
MAJER PAVEL
MACLIN KEITH M
WANG ERIC
SLUSHER BARBARA
LAPIDUS RENA S
MAJER PAVEL
Application Number:
JP2009228198A
Publication Date:
January 07, 2010
Filing Date:
September 30, 2009
Export Citation:
Assignee:
EISAI CORP NORTH AMERICA
International Classes:
C07C323/52; A61K31/194; A61K31/22; A61K31/381; A61P3/10; A61P9/00; A61P13/08; A61P21/04; A61P25/04; A61P25/16; A61P25/18; A61P25/22; A61P43/00; C07D333/32
Domestic Patent References:
| JPH10500111A | 1998-01-06 | |||
| JPS5810558A | 1983-01-21 | |||
| JPS5810565A | 1983-01-21 | |||
| JPS4320003B1 | ||||
| JPS5024442A | 1975-03-15 | |||
| JPS6153285A | 1986-03-17 | |||
| JPS57116045A | 1982-07-19 | |||
| JPH01206338A | 1989-08-18 |
Foreign References:
| WO1998013044A1 | 1998-04-02 | |||
| CN1137896A | 1996-12-18 |
Other References:
JPN6012029083; ＷＡＮＧ，Ｘ． ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ， ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ａｎｄ ａｎｔｉｔｕｍｏｒ ａｃｔｉｖｉｔｙ ｏｆ ｐｏｌｙｎｕｃｌｅａｒ ｓｏｌｉｄ ｃｏｍｐｌｅｘ ｏｆ ｌａｎｔｈａｎｕｍ ｗｉｔｈ ｃｏ' Ｙｉｎｇｙｏｎｇ Ｈｕａｘｕｅ １５（３）, 1998, ３９-４２
JPN6012029081; ＭＩＫＯＹＡＮ，Ｖ．Ｄ． ｅｔ ａｌ．: 'Ｈｙｄｒｏｐｈｏｂｉｃ ａｎｄ ｈｙｄｒｏｐｈｙｌｉｃ Ｆｅ２＋ ｃｏｍｐｌｅｘｅｓ ｗｉｔｈ ｄｅｒｉｖａｔｉｖｅｓ ｏｆ ｄｉｔｈｉｏｃａｒｂａｍａｔｅ ａｓ ｎｉｔｒｉｃ ｏｘｉｄｅ ｔｒａｐｓ' Ｂｉｏｆｉｚｉｋａ ４２（２）, 1997, ４９０-５０１
JPN6012029082; ＩＳＨＩＫＡＷＡ，Ｋ． ｅｔ ａｌ．: 'Ｏｐｔｉｃａｌｌｙ ａｃｔｉｖｅ ａｍｉｎｏ ａｃｉｄｓ． ＸＩＸ． Ｓｏｌｖｅｎｔ ｅｆｆｅｃｔｓ ｏｎ ｏｐｔｉｃａｌ ｒｏｔａｔｏｒｙ ｄｉｓｐｅｒｓｉｏｎ ａｎｄ ｃｉｒｃｕｌａｒ ｄｉｃ' Ｃｈｅｍｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ １９（５）, 1971, ９１２-２９
JPN6012029081; ＭＩＫＯＹＡＮ，Ｖ．Ｄ． ｅｔ ａｌ．: 'Ｈｙｄｒｏｐｈｏｂｉｃ ａｎｄ ｈｙｄｒｏｐｈｙｌｉｃ Ｆｅ２＋ ｃｏｍｐｌｅｘｅｓ ｗｉｔｈ ｄｅｒｉｖａｔｉｖｅｓ ｏｆ ｄｉｔｈｉｏｃａｒｂａｍａｔｅ ａｓ ｎｉｔｒｉｃ ｏｘｉｄｅ ｔｒａｐｓ' Ｂｉｏｆｉｚｉｋａ ４２（２）, 1997, ４９０-５０１
JPN6012029082; ＩＳＨＩＫＡＷＡ，Ｋ． ｅｔ ａｌ．: 'Ｏｐｔｉｃａｌｌｙ ａｃｔｉｖｅ ａｍｉｎｏ ａｃｉｄｓ． ＸＩＸ． Ｓｏｌｖｅｎｔ ｅｆｆｅｃｔｓ ｏｎ ｏｐｔｉｃａｌ ｒｏｔａｔｏｒｙ ｄｉｓｐｅｒｓｉｏｎ ａｎｄ ｃｉｒｃｕｌａｒ ｄｉｃ' Ｃｈｅｍｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ １９（５）, 1971, ９１２-２９
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Toshio Takizawa
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Toshio Takizawa