Title:
ＮＫ細胞培養用組成物、及びそれを利用してＮＫ細胞を培養する方法
Document Type and Number:
Japanese Patent JP7119076
Kind Code:
B2
Abstract:
Provided are a composition for culturing NK cells, and a method of culturing NK cells using the same. According to an aspect, in culturing NK cells from peripheral blood mononuclear cells, when NK cells are cultured in a medium including the composition for culturing NK cells, the composition including IL-15, IL-18, and IL-27, the NK cells may proliferate in large quantities and activation of NK cells may be promoted. Therefore, when the NK cells are used, cancer cell apoptosis or cancer cell-killing ability may be promoted. Accordingly, the NK cells may be used as an effective adoptive immune cell therapy product in cancer prevention or treatment.
Inventors:
Ahn, Hae Jun
Choi, Young Ho
Lim, Eun Jin
Moon, Yong Hwa
Kim, Saehwa
Choi, Young Ho
Lim, Eun Jin
Moon, Yong Hwa
Kim, Saehwa
Application Number:
JP2020513912A
Publication Date:
August 16, 2022
Filing Date:
November 20, 2018
Export Citation:
Assignee:
Sung Kwang Medical Foundation
International Classes:
C12N5/0783; C07K14/54; C07K14/62; C07K14/79
Domestic Patent References:
| JP2006514057A | ||||
| JP2017012010A | ||||
| JP2007538108A |
Other References:
FRIAS A. M. et al.,Experimental Hematology,36 (2008),p.61-68
MARTINEZ A. P. et al.,Clinical grade activated natural killer products for adoptive immunotherapy against high-risk malignancies.,Haematologica,Vol.100 Suppl.1 (2015),p.289-290
ZIBLAT A. et al.,Eur. J. Immunol.,45 (2015),p.192-202
MARTINEZ A. P. et al.,Clinical grade activated natural killer products for adoptive immunotherapy against high-risk malignancies.,Haematologica,Vol.100 Suppl.1 (2015),p.289-290
ZIBLAT A. et al.,Eur. J. Immunol.,45 (2015),p.192-202
Attorney, Agent or Firm:
Hiraki International Patent Office