Title:
【発明の名称】プラヴァスタチン前駆体、ML―236Bの新規製造方法
Document Type and Number:
Japanese Patent JP3062956
Kind Code:
B2
Abstract:
The present invention is related to a new method for producing ML-236B, a precursor of pravastatin sodium, in particular to a method for producing ML-236B lactone form(I), free acid form(II), sodium salt(III) shown in the formulae (I), (II), (III) by using a new microorganism isolated from soil. ML-236B is obtained from the culture broth of this microorganism and it is used as a substrate of pravastatin sodium which is a potent cholesterol-lowering agent used in treatment for hypercholesterolemia.
Inventors:
Chun, Caejeong
Lee, Joo Kyun
Park, Joe-Worn
Theo, Dong-jin
Lee, Sun-Chon
Lee, Joo Kyun
Park, Joe-Worn
Theo, Dong-jin
Lee, Sun-Chon
Application Number:
JP50960898A
Publication Date:
July 12, 2000
Filing Date:
June 30, 1997
Export Citation:
Assignee:
Yung Jin Pharmaceutical Industry Company Limited
International Classes:
A61K31/00; A61K31/215; A61K31/365; A61K31/366; A61P3/00; A61P3/06; C07D309/30; C12N1/14; C12P7/62; C12P7/42; C12P17/06; C12R1/645; (IPC1-7): C12P7/62; C12N1/14; C12P17/06
Attorney, Agent or Firm:
Eiko Funahashi