Title:
【発明の名称】フィブリン特異性を有する組織プラスミノーゲンアクチベーター
Document Type and Number:
Japanese Patent JP3081238
Kind Code:
B2
Abstract:
A tissue plasminogen activator (t-PA) variant is prepared that has an amino acid deletion at positions 466 to 470 of the corresponding wild-type t-PA. This alteration renders the variant fibrin (and plasma clot) specific as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the variant, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The variant may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesin formation or reformation in mammals.
Inventors:
Gil, John F
Presta, Leonard G
Zoller, Mark Jay
Presta, Leonard G
Zoller, Mark Jay
Application Number:
JP50472791A
Publication Date:
August 28, 2000
Filing Date:
February 14, 1991
Export Citation:
Assignee:
Genentech, Inc.
International Classes:
A61P7/02; C12N1/19; C12N5/10; A61K38/46; C12N9/64; C12N9/72; C12N15/09; C12N15/58; A61K38/00; (IPC1-7): C12N9/64; C12N15/09
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)