Title:
METHOD OF STABILIZING INDOLOCARBAZOLE DERIVATIVE
Document Type and Number:
Japanese Patent JPH0733666
Kind Code:
A
Abstract:
PURPOSE: To further stabilize an indolocarbazole useful as an antitumor agent, having excellent long-term storage stability by lyophilizing a solution containing a specific indolocarbazole derivative and a saccharide, having a specific pH range.
CONSTITUTION: A solution containing an indolocarbazole derivative (concentration is preferably 0.1-20mg/ml) of the formula (R is H or lower alkyl) and a saccharide such as lactose (concentration is preferably 1-500mg/ml), having pH5-7, is lyophilized to stabilize the indolocarbazole derivative. The dose of the lyophilized agent is preferably 0.01-20mg/kg weight daily in the case of injection.
Inventors:
KATOU YASUKI
TOMOTA HIROSHI
HAYAKAWA EIJI
KURODA TOKUYUKI
TOMOTA HIROSHI
HAYAKAWA EIJI
KURODA TOKUYUKI
Application Number:
JP18429693A
Publication Date:
February 03, 1995
Filing Date:
July 27, 1993
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK
International Classes:
A61K9/14; A61K9/19; A61K31/55; A61K47/26; A61P35/00; A61P43/00; (IPC1-7): A61K31/55; A61K9/14; A61K31/55; A61K47/26; A61K9/19