Title:
【発明の名称】アロプリノール誘導体および医薬製剤
Document Type and Number:
Japanese Patent JP3067886
Kind Code:
B2
Abstract:
The present invention concerns aminoacyl and oligopeptidyl derivatives of allopurinol (1,5-dihydro-4H-pyrazolo-[3,4-d]-pyrimidin-4-one) of general formula (I), and related salts with pharmacologically-acceptable cations, in which n is an integer between 2 and 6, preferably 5, Y is H or CO-A, in which A is a racemic or chiral amino acid, dipeptide, tripeptide, tetrapeptide, or pentapeptide chosen, respectively, from the goups consisting of: a) arginine, aspartic acid, lysine, leucine; b) glycylaspartate, glycylglycine, aspartylarginine, leucylarginine, alanylglycine; c) arginyllysylaspartate, aspartyllysylarginine, lysylprolylarginine, prolylprolylarginine, lysylhistidylglycinamide, prolylphenylalanylarginine, phenylalanylprolylarginine; d) arginyllysylaspartylvaline, valylaspartyllysylarginine, threonylvalylleucylhistidine; e) arginyllysylaspartylvalyltyrosine. l
Inventors:
Mauro Multi
Patricia Minetti
Clown foresta
Maria Ornella Chinch
Patricia Minetti
Clown foresta
Maria Ornella Chinch
Application Number:
JP6500992A
Publication Date:
July 24, 2000
Filing Date:
March 23, 1992
Export Citation:
Assignee:
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SOCIETA PER AZIONI
International Classes:
A61K31/519; A61K38/00; A61P31/04; A61P35/00; A61P37/00; A61P37/04; C07D487/04; C07K5/04; C07K5/06; C07K5/08; C07K5/10; A61K31/505; C07K7/06; (IPC1-7): C07D487/04; A61K31/519; A61K38/00; A61P31/04; A61P35/00; A61P37/04; C07K5/06; C07K5/08; C07K5/10; C07K7/06
Other References:
Ｃ．Ｒ．Ａｃａｄ．Ｓｃ．Ｐａｒｉｓ．Ｓｅｒｉｅ Ｄ，Ｖｏｌ．２７２，Ｎｏ．４，ｐ．６３９−６４２（１９７１）
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)