Title:
【発明の名称】ホスホノギ酸三ナトリウム6水和物の製法
Document Type and Number:
Japanese Patent JP2568341
Kind Code:
B2
Abstract:
The present invention relates to a method for the synthesis of foscarnet, i.e. trisodium phosphonoformate hexahydrate, comprising the steps of adding sodium hydroxide to water, heating the aqueous sodium hydroxide solution to 50 DEG C, adding triethyl phosphonoformate to said solution at 50 DEG C, heating the reaction mixture to reflux for about 1 hour, cooling of the reaction mixture and filtering-off of the product.
Inventors:
Yak Povuit, Edave
Stenhede, Urban
Stenhede, Urban
Application Number:
JP50589491A
Publication Date:
January 08, 1997
Filing Date:
March 06, 1991
Export Citation:
Assignee:
Actie Boraget Astra
International Classes:
C07F9/38; (IPC1-7): C07F9/38
Domestic Patent References:
| JP62212396A |
Other References:
【文献】欧州特許20241686(EP,A)
【文献】独国特許1243500(DE,A)
【文献】Chemical Abstracts,volume110,No.23,776頁213075e(CS,B1,253848)
【文献】独国特許1243500(DE,A)
【文献】Chemical Abstracts,volume110,No.23,776頁213075e(CS,B1,253848)
Attorney, Agent or Firm:
Chika Takagi (2 outside)