Title:
水溶性薬物を含有する経口投与用ナノ粒子組成物及びその製造方法
Document Type and Number:
Japanese Patent JP4814107
Kind Code:
B2
Abstract:
The present invention relates to an orally administrable composition containing nanoparticles with the particle size of 500 nm or less, comprising 0.1-30 weight % of a complex of a water-soluble drug and a counter-ion substance in which the charged water-soluble drug is bonded with the counter-ion substance, 0.5-80 weight % of a lipid, 0.5-80 weight % of a polymer, and 1-80 weight % of an emulsifier, wherein the weight ratio of said lipid and said polymer is in the range of 1:0.05-3, and a preparation method thereof. The composition of the present invention has high gastrointestinal absorption rate upon oral administration, and has high drug entrapping rate in the nanoparticle, and is also stable against lipases.
Inventors:
Bae, Chul-Min
Min, Mi Hong
Fan, Jun-Suk
Cho, Kyung-Mi
Min, Mi Hong
Fan, Jun-Suk
Cho, Kyung-Mi
Application Number:
JP2006546830A
Publication Date:
November 16, 2011
Filing Date:
December 24, 2004
Export Citation:
Assignee:
SAMYANG CORPORATION
International Classes:
A61K9/14; A61K47/44; A61K9/08; A61K9/10; A61K9/51; A61K31/185; A61K31/545; A61K31/66; A61K31/7012; A61K31/727; A61K38/23; A61K38/27; A61K38/28; A61K47/02; A61K47/06; A61K47/10; A61K47/12; A61K47/14; A61K47/18; A61K47/20; A61K47/24; A61K47/26; A61K47/28; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/42; A61P3/10; A61P31/04
Domestic Patent References:
| JPS6289617A | 1987-04-24 | |||
| JP2000024487A | 2000-01-25 | |||
| JP2002531394A | 2002-09-24 | |||
| JP2002080399A | 2002-03-19 |
Foreign References:
| WO2002074316A1 | 2002-09-26 |
Attorney, Agent or Firm:
Kyuichi Ueki
Tadashi Sugakawa
Osamu Futakuchi
Hiroaki Ito
Tadashi Sugakawa
Osamu Futakuchi
Hiroaki Ito