NANOTUBE AS MITOCHONDRIAL UNCOUPLER - UNIV KENTUCKY RES FOUND

Title:

NANOTUBE AS MITOCHONDRIAL UNCOUPLER

Document Type and Number:

Japanese Patent JP2013173761

Kind Code:

A

Abstract:

To provide a method of uncoupling mitochondria in a subject.

A method of uncoupling mitochondria in a subject including a step of administering nanotubes to the subject in a therapeutically effective amount, wherein the nanotubes are self-rectifying is provided. A method of decreasing reactive oxygen species and decreasing detrimental loading of Ca²⁺ into mitochondria is provided, including a step of administering a pharmaceutically effective amount of nanotubes into the subject, wherein the nanotubes are self-rectifying. A method of reducing weight, treating cancer, reducing the effects of traumatic brain injury, or reducing the effects of ageing, in a subject including administering a pharmaceutically effective amount of nanotubes into the subject is also provided.

Inventors:

SULLIVAN PATRICK G

Application Number:

JP2013082480A

Publication Date:

September 05, 2013

Filing Date:

April 10, 2013

Export Citation:

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Assignee:

UNIV KENTUCKY RES FOUND

International Classes:

A61K33/44; A61K31/715; A61K31/717; A61K31/718; A61K31/722; A61K31/765; A61K31/77; A61K31/785; A61K33/242; A61K33/243; A61K33/38; A61K47/22; A61K47/34; A61P9/00; A61P25/00; A61P43/00; A61K33/24

Foreign References:

WO2004041256A2	2004-05-21
US6613875B1	2003-09-02

Other References:

JPN6011058502; Ｂｒｏｗｎ　ＭＲ　ｅｔ　ａｌ．: 'Ｂｒａｉｎ　ｒｅｇｉｏｎ-ｓｐｅｃｉｆｉｃ，　ａｇｅ-ｒｅｌａｔｅｄ，　ａｌｔｅｒａｔｉｏｎｓ　ｉｎ　ｍｉｔｏｃｈｏｎｄｒｉａｌ　ｒｅｓｐｏｎｓｅｓ　ｔｏ　ｅｌｅｖａｔｅｄ　ｃａｌｃｉｕｍ．' Ｊ　Ｂｉｏｅｎｅｒｇ　Ｂｉｏｍｅｍｂｒ．Ｖｏｌ．３６　ｎｏ．４, 200408, ｐｐ．４０１-４０６
JPN6011058507; Ｍａｒｔｉｎ　ＣＲ　ａｎｄ　Ｋｏｈｌｉ　Ｐ．: 'Ｔｈｅ　ｅｍｅｒｇｉｎｇ　ｆｉｅｌｄ　ｏｆ　ｎａｎｏｔｕｂｅ　ｂｉｏｔｅｃｈｎｏｌｏｇｙ．' Ｎａｔ　Ｒｅｖ　Ｄｒｕｇ　Ｄｉｓｃｏｖ．Ｖｏｌ．２　ｎｏ．１, 200301, ｐｐ．２９-３７
JPN6011058504; Ｈａｒｐｅｒ　ＪＡ　ｅｔ　ａｌ．: 'Ｍｉｔｏｃｈｏｎｄｒｉａｌ　ｕｎｃｏｕｐｌｉｎｇ　ａｓ　ａ　ｔａｒｇｅｔ　ｆｏｒ　ｄｒｕｇ　ｄｅｖｅｌｏｐｍｅｎｔ　ｆｏｒ　ｔｈｅ　ｔｒｅａｔｍｅｎｔ　ｏｆ　ｏｂｅｓｉｔｙ．' Ｏｂｅｓ　Ｒｅｖ．Ｖｏｌ．２　ｎｏ．４, 200111, ｐｐ．２５５-２６５
JPN6011058493; Ｍａｒｔｉｎ　ＣＲ　ｅｔ　ａｌ．: 'Ｖｏｌｔａｇｅ　ｇａｔｉｎｇ　ｉｎ　ｓｙｎｔｈｅｔｉｃ　ｓｉｎｇｌｅ-ｎａｎｏｔｕｂｅ　ｍｅｍｂｒａｎｅｓ．' Ｂｉｏｐｈｙｓｉｃａｌ　Ｊｏｕｒｎａｌ，Ｖｏｌ．８６　Ｎｏ．１, 200401, ｐ．１３１ａ
JPN6011058495; 二木　史朗: '合成ペプチドによるイオンチャネル機能の創出' 有機合成化学協会誌Ｖｏｌ．５６　ｎｏ．２, 1998, ｐｐ．１２５-１３３
JPN6011058498; Ｓｕｌｌｉｖａｎ　ＰＧ　ｅｔ　ａｌ．: 'Ｍｉｔｏｃｈｏｎｄｒｉａｌ　ｕｎｃｏｕｐｌｉｎｇ　ａｓ　ａ　ｔｈｅｒａｐｅｕｔｉｃ　ｔａｒｇｅｔ　ｆｏｌｌｏｗｉｎｇ　ｎｅｕｒｏｎａｌ　ｉｎｊｕｒｙ．' Ｊ　Ｂｉｏｅｎｅｒｇ　Ｂｉｏｍｅｍｂｒ．Ｖｏｌ．３６　ｎｏ．４, 200408, ｐｐ．３５３-３５６
JPN6011058502; Ｂｒｏｗｎ　ＭＲ　ｅｔ　ａｌ．: 'Ｂｒａｉｎ　ｒｅｇｉｏｎ-ｓｐｅｃｉｆｉｃ，　ａｇｅ-ｒｅｌａｔｅｄ，　ａｌｔｅｒａｔｉｏｎｓ　ｉｎ　ｍｉｔｏｃｈｏｎｄｒｉａｌ　ｒｅｓｐｏｎｓｅｓ　ｔｏ　ｅｌｅｖａｔｅｄ　ｃａｌｃｉｕｍ．' Ｊ　Ｂｉｏｅｎｅｒｇ　Ｂｉｏｍｅｍｂｒ．Ｖｏｌ．３６　ｎｏ．４, 200408, ｐｐ．４０１-４０６
JPN6011058507; Ｍａｒｔｉｎ　ＣＲ　ａｎｄ　Ｋｏｈｌｉ　Ｐ．: 'Ｔｈｅ　ｅｍｅｒｇｉｎｇ　ｆｉｅｌｄ　ｏｆ　ｎａｎｏｔｕｂｅ　ｂｉｏｔｅｃｈｎｏｌｏｇｙ．' Ｎａｔ　Ｒｅｖ　Ｄｒｕｇ　Ｄｉｓｃｏｖ．Ｖｏｌ．２　ｎｏ．１, 200301, ｐｐ．２９-３７

Attorney, Agent or Firm:

Yasunori Otsuka
Shiro Takayanagi
Yasuhiro Otsuka
Shuji Kimura
Osamu Shimoyama

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