NAPHTHOQUINONE DERIVATIVE COMPOUND OR ITS PHARMACEUTICALLY PERMISSIBLE SALT AND Cdc25 PHOSPHATASE INHIBITOR AND ANTITUMOR AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT

Title:

NAPHTHOQUINONE DERIVATIVE COMPOUND OR ITS PHARMACEUTICALLY PERMISSIBLE SALT AND Cdc25 PHOSPHATASE INHIBITOR AND ANTITUMOR AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT

Document Type and Number:

Japanese Patent JP2005220037

Kind Code:

A

Abstract:

To obtain a naphthoquinone derivative compound or its pharmaceutically permissible salt having high inhibitory activity against Cdc25 phosphatase and a Cdc25 phosphatase inhibitor and an antitumor agent containing the same as an active ingredient.

The naphthoquinone derivative compound represented by general formula (I) (R1 and R2 are each an alkoxy group; R3 is a hydrogen atom; R4 is an alkoxyalkyl group) or its pharmaceutically permissible salt has high inhibitory activity against Cdc25 phosphatase. Consequently, a substance containing the naphthoquinone derivative compound or its pharmaceutically permissible salt as an active ingredient is considered to be useful as a Cdc25 phosphatase inhibitor and an antitumor agent.

Inventors:

NISHIYAMA SHIGERU
IMOTO MASAYA
SHINBASHI AKIKO
TSUCHIYA AYAKO

Application Number:

JP2004027055A

Publication Date:

August 18, 2005

Filing Date:

February 03, 2004

Export Citation:

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Assignee:

KEIO GIJUKU

International Classes:

C07D319/06; A61K31/122; A61K31/352; A61K31/357; A61P35/00; C07C50/12; C07C50/14; C07C225/26; C07D311/92; (IPC1-7): C07C50/12; A61K31/122; A61K31/352; A61K31/357; A61P35/00; C07C50/14; C07C225/26; C07D311/92; C07D319/06

Attorney, Agent or Firm:

Isshiki International Patent Service Corporation

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