NEW MATERIAL:A compound expressed by formula I (R1 is H or lower alkyl; R2 is H, lower alkenyl, phenyl lower alkyl or alkyl which may have OH).
EXAMPLE: 2(1-Hydroxyethyl)-5,8-dimethoxy-1,4-naphthoquinone.
USE: An anti-inflammatory and analgesic agent, remedy for cardiopathy, antiallergic agent, antithrombotic agent, antitumor agent and antimicrobial agent.
PREPARATION: (i) A compound expressed by formula II is subjected to the Grignard reaction to give a compound expressed by formula III (R3 is lower alkenyl, phenyl lower alkyl or alkyl), which is then oxidized. (ii) Alternatively, the compound expressed by formula II is reacted with a Grignard reagent prepared from magnesium and a benzyloxyalkyl halide, and the resultant compound expressed by formula IV (R4 is benzyloxyalkyl) is catalytically reduced, debenzylated and further oxidized to afford the aimed compound expressed by formula I (R2 is other than H).
GOTO KIYOTO
TSUDA YOSHIAKI
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