Title:
NAPROXEN NITROXYALKYL ESTER
Document Type and Number:
Japanese Patent JP2011042690
Kind Code:
A
Abstract:
To obtain a naproxen nitroxyalkyl ester having an enantiomeric excess of at least 97%, preferably 98% or higher.
A halide of 2-(S)-(6-methoxy-2-naphthyl)-propionic acid of formula A-Hal (wherein A is an acyl residue of an acid) is reacted with an aliphatic nitroxyalkanol HO-Y-ONO2 (wherein Y is a 1C-20C alkylene group or a 3C-8C cycloalkylene group or an alkylene group as defined and including a cycloalkylene group as defined) in an inactive organic solvent under the presence of an inorganic base. Thus is produced a nitroxyalkyl ester of 2-(S)-(6-methoxy-2-naphthyl)-propionic acid having an enantiomeric excess of at least 97%, preferably 98% or higher.
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Inventors:
BENEDINI FRANCESCA
OLDANI ERMINIO
CASTALDI GRAZIANO
TARQUINI ANTONIO
OLDANI ERMINIO
CASTALDI GRAZIANO
TARQUINI ANTONIO
Application Number:
JP2010266860A
Publication Date:
March 03, 2011
Filing Date:
November 30, 2010
Export Citation:
Assignee:
NICOX SA
International Classes:
C07C201/02; C07B53/00; C07C203/04; C07B61/00
Domestic Patent References:
| JPH09512798A | 1997-12-22 | |||
| JPH09503214A | 1997-03-31 |
Foreign References:
| WO1998025918A1 | 1998-06-18 | |||
| CN1144092A | 1997-03-05 |
Other References:
JPN6010050761; Ｐｈａｒｍａｃｏｌｏｇｉｃａｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．３１， Ｎｏ．１, ｐ．６１-６５ （１９９５）．
Attorney, Agent or Firm:
Shintaro Nogawa