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Title:
ネプリライシン阻害剤
Document Type and Number:
Japanese Patent JP2014503534
Kind Code:
A
Abstract:
In one aspect, the invention relates to compounds having the formula:where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

Inventors:
Gendron, Roland
Fleurie, Melissa
Hughes, Adam Dee.
Application Number:
JP2013544730A
Publication Date:
February 13, 2014
Filing Date:
December 14, 2011
Export Citation:
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Assignee:
Theravans, Incorporated
International Classes:
C07D213/81; A61K31/341; A61K31/381; A61K31/41; A61K31/415; A61K31/4155; A61K31/4162; A61K31/4166; A61K31/4178; A61K31/4192; A61K31/4196; A61K31/42; A61K31/421; A61K31/422; A61K31/423; A61K31/4245; A61K31/426; A61K31/437; A61K31/4439; A61K31/454; A61K31/465; A61K31/4965; A61K31/497; A61K31/50; A61K31/505; A61K31/5365; A61K31/5377; A61K31/553; A61K45/00; A61P9/04; A61P9/12; A61P13/12; A61P43/00; C07D231/14; C07D233/90; C07D237/04; C07D237/24; C07D239/28; C07D239/36; C07D241/24; C07D249/04; C07D249/10; C07D249/12; C07D249/18; C07D257/04; C07D261/18; C07D263/34; C07D263/56; C07D271/06; C07D277/20; C07D277/56; C07D307/68; C07D333/68; C07D401/04; C07D401/06; C07D401/12; C07D403/04; C07D403/06; C07D403/12; C07D403/14; C07D405/04; C07D405/12; C07D409/04; C07D413/04; C07D471/04; C07D498/04
Domestic Patent References:
JP2008530045A2008-08-07
JPH05310664A1993-11-22
JP2008530045A2008-08-07
JPH05310664A1993-11-22
Foreign References:
WO2010136474A22010-12-02
WO2010136493A12010-12-02
WO2010136474A22010-12-02
WO2010136493A12010-12-02
Other References:
JPN5014002280; GARY M KSANDER: 'DICARBOXYLIC ACID DIPEPTIDE NEUTRAL ENDOPEPTIDASE INHIBITORS' JOURNAL OF MEDICINAL CHEMISTRY V38 N10, 19950501, P1689-1700, AMERICAN CHEMICAL SOCIETY
JPN5014002280; GARY M KSANDER: 'DICARBOXYLIC ACID DIPEPTIDE NEUTRAL ENDOPEPTIDASE INHIBITORS' JOURNAL OF MEDICINAL CHEMISTRY V38 N10, 19950501, P1689-1700, AMERICAN CHEMICAL SOCIETY
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita