Title:
ニューロステロイド化合物
Document Type and Number:
Japanese Patent JP2010530404
Kind Code:
A
Abstract:
The present invention relates to novel neurosteroid derivatives with anti-apoptotic, neuroprotective and neurogenic properties that act on the nervous system as well as methods for making the same and their applications in the treatment and/or prevention or amelioration of neurodegenerative diseases related to neuronal apoptosis or neuronal injury, or conditions related to or resulting from apoptosis, including but not limited to Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis (ALS), retinal degeneration and detachment, peripheral neuropathy caused by genetic abnormalities, diabetes, polio, herpes, AIDS and chemotherapy, brain trauma, or ischemia and stroke. The active compounds are represented by Formula (I): wherein R1, R2, R3, R4, R5, R6, R7, A, B, X, Y and Z are defined in the description of the invention. The present invention also includes compositions which comprise one or more of the compounds of Formula (I).
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Inventors:
Gravanice, Achilleas
Carogello Pourou, Theodora
Castanas, Elias
Margioris, Andreas
Chara Rambo Poulos, Ioannis
Avronitis, Nikolaos
Minas, Vasilios
Alexaki, Vasileia-Ismini
Tusat Sanis, Christos
Alexis, Michael, N.
Lenbo Tsuka, Eumofia
Vergau, Vervara
Neophyto, Constantinos
Carogello Pourou, Theodora
Castanas, Elias
Margioris, Andreas
Chara Rambo Poulos, Ioannis
Avronitis, Nikolaos
Minas, Vasilios
Alexaki, Vasileia-Ismini
Tusat Sanis, Christos
Alexis, Michael, N.
Lenbo Tsuka, Eumofia
Vergau, Vervara
Neophyto, Constantinos
Application Number:
JP2010512762A
Publication Date:
September 09, 2010
Filing Date:
June 17, 2008
Export Citation:
Assignee:
BIONATURE E.A. LIMITED
International Classes:
C07J21/00; A61K31/58; A61P3/10; A61P9/00; A61P17/00; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/00; A61P27/02; A61P37/00
Domestic Patent References:
| JP2001510471A | 2001-07-31 | |||
| JPS51128959A | 1976-11-10 | |||
| JPS5059361A | 1975-05-22 | |||
| JP2001510471A | 2001-07-31 | |||
| JPS51128959A | 1976-11-10 | |||
| JPS5059361A | 1975-05-22 | |||
| JPS4943962A | 1974-04-25 |
Foreign References:
| US3939155A | 1976-02-17 | |||
| US3094521A | 1963-06-18 | |||
| US3364238A | 1968-01-16 | |||
| US3939155A | 1976-02-17 | |||
| US3094521A | 1963-06-18 | |||
| US3364238A | 1968-01-16 |
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JPN6013017176; Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ ９５（３）, 1980, １１３１-１１３７
JPN6013017178; Ｓｔｅｒｏｉｄｓ ６７, 2002, ６８７-６９３
JPN6013017179; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ６, 1998, １６８３-１６９３
JPN6013017181; Ｔｅｔｒａｈｅｄｒｏｎ ２９, 1973, ８８３-８８９
JPN7013001364; Ｃｈｅｍｉｓｃｈｅ Ｂｅｒｉｃｈｔｅ ９７, 1964, ３５２９-３５３５
JPN6013017183; Ｔｅｔｒａｈｅｄｒｏｎ ４３（３）, 1987, ６３１-６４１
JPN6014026041; Ｔｅｔｒａｈｅｄｒｏｎ ３０, 1974, ６０３-６０８
JPN6014026043; Ｂｕｌｌｅｔｉｎ ｄｅ ｌａ Ｓｏｃｉｅｔｅ Ｃｈｉｍｉｑｕｅ ｄｅ Ｆｒａｎｃｅ （１２）, 1963, ２７９３-２８００
Attorney, Agent or Firm:
Patent corporation ssinpat