Title:
神経活性ステロイドおよび調製の方法
Document Type and Number:
Japanese Patent JP7443358
Kind Code:
B2
Abstract:
Neuroactive steroid anaesthetic agents, methods for their preparation and compositions comprising the same are disclosed. Also provided are scaled up and/or GMP methods for preparing neuroactive steroids, such as alfaxalone, alfadolone and alfadolone acetate.
Inventors:
edmonds ian
Hessler Edward Jay.
Hessler Edward Jay.
Application Number:
JP2021522112A
Publication Date:
March 05, 2024
Filing Date:
July 03, 2019
Export Citation:
Assignee:
Drawbridge Pharmaceuticals Pty Ltd.
International Classes:
C07J7/00; A61K31/57; A61P23/00
Foreign References:
| US20150265632 | ||||
| WO2011088503A1 |
Other References:
BROWNE, P. A. et al.,A study of the henbest reduction: the preparation of 3a-hydroxy-5a and 3beta-hydroxy-5beta-steroids,JOURNAL OF THE CHEMICAL SOCIETY. C. ORGANIC,1969年,pp.1653-1659
EUW, J. V. et al.,Ueber bestandteile der nebennierenrinde und verwandte stoffe. 68. Mitteilung. pregnandiol-(3.alpha., 11.alpha)-on-(20) und pregnandiol-(3.beta., 11.alpha.)-on-(20),HELVETICA CHIMICA ACTA,1944年,Vol.27, No.1,pp.821-839,DOI:10.1002/hlca.194402701107
PHILLIPPS, G. H.,STRUCTURE-ACTIVITY RELATIONSHIPS IN STEROIDAL ANAESTHETICS,Journal of Steroid Biochemistry,Vol. 6,1975年,pp.607-613,DOI:10.1016/0022-4731(75)9001-2
ZHANGA, Zonglei,First Synthesis of a C-Homosteroid from Pregn-4-ene-3,11,20-trione,Helvetica Chimica Acta,2011年,Vol.94,pp.98-104
HILL, C. K. and HARTWIG, J. F.,Site-selective oxidation, amination and epimerization reactions of complex polyols enabled by transfer hydrogenation,Nat Chem. Author manuscript,2017年,pp.1-18,DOI:10.1038/nchem.2835.,Nat Chem. 2017 December ; 9(12): 1213-1221.
EUW, J. V. et al.,Ueber bestandteile der nebennierenrinde und verwandte stoffe. 68. Mitteilung. pregnandiol-(3.alpha., 11.alpha)-on-(20) und pregnandiol-(3.beta., 11.alpha.)-on-(20),HELVETICA CHIMICA ACTA,1944年,Vol.27, No.1,pp.821-839,DOI:10.1002/hlca.194402701107
PHILLIPPS, G. H.,STRUCTURE-ACTIVITY RELATIONSHIPS IN STEROIDAL ANAESTHETICS,Journal of Steroid Biochemistry,Vol. 6,1975年,pp.607-613,DOI:10.1016/0022-4731(75)9001-2
ZHANGA, Zonglei,First Synthesis of a C-Homosteroid from Pregn-4-ene-3,11,20-trione,Helvetica Chimica Acta,2011年,Vol.94,pp.98-104
HILL, C. K. and HARTWIG, J. F.,Site-selective oxidation, amination and epimerization reactions of complex polyols enabled by transfer hydrogenation,Nat Chem. Author manuscript,2017年,pp.1-18,DOI:10.1038/nchem.2835.,Nat Chem. 2017 December ; 9(12): 1213-1221.
Attorney, Agent or Firm:
Shinji Kato
Mamoru Suzuki
Keiko Kanemoto
Mamoru Suzuki
Keiko Kanemoto